| pubmed-article:8522056 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8522056 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:8522056 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:8522056 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:8522056 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:8522056 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:8522056 | lifeskim:mentions | umls-concept:C1420175 | lld:lifeskim |
| pubmed-article:8522056 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:8522056 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:8522056 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:8522056 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8522056 | pubmed:dateCreated | 1996-1-25 | lld:pubmed |
| pubmed-article:8522056 | pubmed:abstractText | Dysregulation of GLUT4, the insulin-responsive glucose transporter, is associated with insulin resistance in skeletal muscle. Although skeletal muscle is the major target of insulin action, muscle GLUT4 has not been linked causally to whole-body insulin sensitivity and regulation of glucose homeostasis. To address this, we generated a line of transgenic mice that overexpresses GLUT4 in skeletal muscle. We demonstrate that restricted overexpression of GLUT4 in fast-twitch skeletal muscles of myosin light chain (MLC)-GLUT4 transgenic mice induces a 2.5-fold increase in insulin-stimulated 2-deoxyglucose uptake in transgene-overexpressing cells. Consequently, glycogen content is increased in the fast-twitch skeletal muscles under insulin action (5.75 +/- 1.02 vs. 3.24 +/- 0.26 mg/g). This indicates that insulin-stimulated glucose transport is partly rate-limiting for glycogen synthesis. At the whole-body level, insulin-stimulated glucose turnover is increased 2.5-fold in unconscious MLC-GLUT4 mice. Plasma glucose and insulin levels in MLC-GLUT4 mice are altered as a result of increased insulin action. In 2- to 3-month-old MLC-GLUT4 mice, fasting insulin levels are decreased (0.43 +/- 0.05 vs. 0.74 +/- 0.10 microgram/l), whereas normal fasting glycemia is maintained. Conversely, 7- to 9-month-old MLC-GLUT4 mice exhibit decreased fasting glycemia (5.75 +/- 0.73 vs. 8.11 +/- 0.57 mmol/l) with normal insulin levels. Fasting plasma lactate levels are elevated in both age groups (50-100%). Additionally lipid metabolism is affected by skeletal muscle GLUT4 overexpression. This is indicated by changes in plasma free fatty acid and beta-hydroxybutyrate levels. These studies underscore the importance of GLUT4 in the regulation of glucose homeostasis and its interaction with lipid metabolism. | lld:pubmed |
| pubmed-article:8522056 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8522056 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8522056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8522056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8522056 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8522056 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8522056 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:8522056 | pubmed:author | pubmed-author:KatsE IEI | lld:pubmed |
| pubmed-article:8522056 | pubmed:author | pubmed-author:HuangLL | lld:pubmed |
| pubmed-article:8522056 | pubmed:author | pubmed-author:BurcelinRR | lld:pubmed |
| pubmed-article:8522056 | pubmed:author | pubmed-author:CharronM JMJ | lld:pubmed |
| pubmed-article:8522056 | pubmed:author | pubmed-author:TsaiT YTY | lld:pubmed |
| pubmed-article:8522056 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8522056 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:8522056 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8522056 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8522056 | pubmed:pagination | 28-36 | lld:pubmed |
| pubmed-article:8522056 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:8522056 | pubmed:meshHeading | pubmed-meshheading:8522056-... | lld:pubmed |
| pubmed-article:8522056 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8522056 | pubmed:articleTitle | Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle. | lld:pubmed |
| pubmed-article:8522056 | pubmed:affiliation | Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA. | lld:pubmed |
| pubmed-article:8522056 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8522056 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8522056 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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