| pubmed-article:8514857 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8514857 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8514857 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:8514857 | lifeskim:mentions | umls-concept:C0574032 | lld:lifeskim |
| pubmed-article:8514857 | lifeskim:mentions | umls-concept:C1154417 | lld:lifeskim |
| pubmed-article:8514857 | lifeskim:mentions | umls-concept:C0445550 | lld:lifeskim |
| pubmed-article:8514857 | lifeskim:mentions | umls-concept:C1637379 | lld:lifeskim |
| pubmed-article:8514857 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8514857 | pubmed:dateCreated | 1993-7-21 | lld:pubmed |
| pubmed-article:8514857 | pubmed:abstractText | To determine if insulin-like growth factor I (IGF-I) inhibits pulsatile growth hormone (GH) secretion in man, recombinant human IGF-I (rhIGF-I) was infused for 6 h at 10 micrograms.kg-1.h-1 during a euglycemic clamp in 10 normal men who were fasted for 32 h to enhance GH secretion. Saline alone was infused during an otherwise identical second admission as a control. As a result of rhIGF-I infusion, total and free IGF-I concentrations increased three- and fourfold, respectively. Mean GH concentrations fell from 6.3 +/- 1.6 to 0.59 +/- 0.07 micrograms/liter after 120 min. GH secretion rates, calculated by a deconvolution algorithm, decreased with a t 1/2 of 16.6 min and remained suppressed thereafter. Suppression of GH secretion rates occurred within 60 min when total and free IGF-I concentrations were 1.6-fold and 2-fold above baseline levels, respectively, and while glucose infusion rates were < 1 mumol.kg-1.min-1. During saline infusion, GH secretion rates remained elevated. Infusion of rhIGF-I decreased the mass of GH secreted per pulse by 84% (P < 0.01) and the number of detectable GH secretory pulses by 32% (P < 0.05). Plasma insulin and glucagon decreased to nearly undetectable levels after 60 min of rhIGF-I. Serum free fatty acids, beta-hydroxybutyrate, and acetoacetate were unaffected during the first 3 h of rhIGF-I but decreased thereafter to 52, 32, and 50% of levels observed during saline. We conclude that fasting-enhanced GH secretion is rapidly suppressed by a low-dose euglycemic infusion of rhIGF-I. This effect of rhIGF-I is likely mediated through IGF-I receptors independently of its insulin-like metabolic actions. | lld:pubmed |
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| pubmed-article:8514857 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8514857 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8514857 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8514857 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8514857 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8514857 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:8514857 | pubmed:author | pubmed-author:AlbertiK GKG | lld:pubmed |
| pubmed-article:8514857 | pubmed:author | pubmed-author:JohnsonM LML | lld:pubmed |
| pubmed-article:8514857 | pubmed:author | pubmed-author:ThornerM OMO | lld:pubmed |
| pubmed-article:8514857 | pubmed:author | pubmed-author:PerlmanA JAJ | lld:pubmed |
| pubmed-article:8514857 | pubmed:author | pubmed-author:ClaytonP EPE | lld:pubmed |
| pubmed-article:8514857 | pubmed:author | pubmed-author:HartmanM LML | lld:pubmed |
| pubmed-article:8514857 | pubmed:author | pubmed-author:CelnikerAA | lld:pubmed |
| pubmed-article:8514857 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8514857 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:8514857 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8514857 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8514857 | pubmed:pagination | 2453-62 | lld:pubmed |
| pubmed-article:8514857 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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