| pubmed-article:8513590 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8513590 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:8513590 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:8513590 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:8513590 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:8513590 | lifeskim:mentions | umls-concept:C0035450 | lld:lifeskim |
| pubmed-article:8513590 | lifeskim:mentions | umls-concept:C0457083 | lld:lifeskim |
| pubmed-article:8513590 | lifeskim:mentions | umls-concept:C1706089 | lld:lifeskim |
| pubmed-article:8513590 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8513590 | pubmed:dateCreated | 1993-7-16 | lld:pubmed |
| pubmed-article:8513590 | pubmed:abstractText | Rheumatoid arthritis is an autoimmune disease which is characterized by chronic polyarthritis and joint destruction as well as by extra-articular manifestations, typically including the appearance of rheumatoid nodules. Although the pathogenesis of the disease is unknown, substantial evidence suggests that it is T cell-mediated. In contrast to experimental models, the disease-mediating T cells in the human situation have never been isolated or identified. We expanded T lymphocytes from human rheumatoid nodules by IL-2 stimulation and observed a marked oligoclonality among these expanded lymphocytes. This tendency towards oligoclonality was not seen in IL-2-expanded lymphocytes from peripheral blood. We hypothesize that this oligoclonal expansion reflects a clonally restricted in situ preactivation of lymphocytes and that precisely these preactivated cells are involved in the pathogenesis of the rheumatic process. | lld:pubmed |
| pubmed-article:8513590 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8513590 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8513590 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8513590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8513590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8513590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8513590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8513590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8513590 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8513590 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8513590 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:8513590 | pubmed:author | pubmed-author:VeysE MEM | lld:pubmed |
| pubmed-article:8513590 | pubmed:author | pubmed-author:VerbruggenGG | lld:pubmed |
| pubmed-article:8513590 | pubmed:author | pubmed-author:CuvelierCC | lld:pubmed |
| pubmed-article:8513590 | pubmed:author | pubmed-author:De KeyserFF | lld:pubmed |
| pubmed-article:8513590 | pubmed:author | pubmed-author:BenoitDD | lld:pubmed |
| pubmed-article:8513590 | pubmed:author | pubmed-author:MalfaitA MAM | lld:pubmed |
| pubmed-article:8513590 | pubmed:author | pubmed-author:ElewautDD | lld:pubmed |
| pubmed-article:8513590 | pubmed:author | pubmed-author:VermeerschJJ | lld:pubmed |
| pubmed-article:8513590 | pubmed:author | pubmed-author:HeirweghAA | lld:pubmed |
| pubmed-article:8513590 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8513590 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:8513590 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8513590 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8513590 | pubmed:pagination | 29-34 | lld:pubmed |
| pubmed-article:8513590 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
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| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:meshHeading | pubmed-meshheading:8513590-... | lld:pubmed |
| pubmed-article:8513590 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8513590 | pubmed:articleTitle | T cell receptor V beta usage in rheumatoid nodules: marked oligoclonality among IL-2 expanded lymphocytes. | lld:pubmed |
| pubmed-article:8513590 | pubmed:affiliation | Department of Rheumatology, University Hospital, Ghent, Belgium. | lld:pubmed |
| pubmed-article:8513590 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8513590 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8513590 | lld:pubmed |
