Linked Life Data

8513480

Source:http://linkedlifedata.com/resource/pubmed/id/8513480

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pubmed-article:8513480pubmed:abstractTextInterstitial cells in the pineal gland of the rat were characterized immunocytochemically using the monoclonal antibodies MRC OX-42 and ED1 for macrophages/microglia, and MRC OX-6, which recognizes major histocompatibility complex (MHC) class II antigen. A polyclonal antibody against GFAP was used to identify astrocytes. Cells immunopositive for OX-42 and/or ED1 were distributed throughout the gland; they extended processes primarily along the perivascular spaces and occasionally within the parenchyma of the gland. Ultrastructurally, these OX-42-positive cells were characterized by a nucleus with sparse heterochromatin and cytoplasmic vacuoles/lysosomes. Cells expressing MHC class II antigen had a distribution and morphology similar to OX-42-immunopositive cells, suggesting that pineal macrophages/microglia play a role as antigen-presenting cells. GFAP-positive astrocytes were concentrated at the proximal end of the pineal where the pineal stalk enters the gland. The occurrence of antigen-presenting cells in this circumventricular neuroendocrine gland has important functional implications as these cells may be mediators of neuroimmunomodulatory mechanisms, and involved in certain disease states such as autoimmune pinealitis.lld:pubmed
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pubmed-article:8513480pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8513480pubmed:articleTitleImmunocytochemical and electron-microscopic characterization of macrophage/microglia cells and expression of class II major histocompatibility complex in the pineal gland of the rat.lld:pubmed
pubmed-article:8513480pubmed:affiliationPharmaBiotec, University of Aarhus, Denmark.lld:pubmed
pubmed-article:8513480pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8513480pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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