| pubmed-article:8505084 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8505084 | lifeskim:mentions | umls-concept:C0034705 | lld:lifeskim |
| pubmed-article:8505084 | lifeskim:mentions | umls-concept:C0006669 | lld:lifeskim |
| pubmed-article:8505084 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8505084 | pubmed:issue | 6 Pt 2 | lld:pubmed |
| pubmed-article:8505084 | pubmed:dateCreated | 1993-7-2 | lld:pubmed |
| pubmed-article:8505084 | pubmed:abstractText | Calcitonin gene-related peptide, a product of the calcitonin gene, is a potent vasodilator neuropeptide. We have demonstrated that dietary calcium deficiency decreased the neuronal (laminae I/II of the dorsal horn of the spinal cord) content of immunoreactive calcitonin gene-related peptide in the normal rat. Neuronal calcitonin gene-related peptide levels are also reduced in the spontaneously hypertensive rat, a model characterized by calcium deficiency. However, the mechanism of this reduction in neuronal calcitonin gene-related peptide could be due to decreased synthesis or increased release. To determine if neuronal calcitonin gene-related peptide messenger RNA (mRNA) levels are also decreased in the spontaneously hypertensive rat, we measured relative calcitonin gene-related peptide mRNA levels (using a genomic hybridization probe specific for alpha- and beta-calcitonin gene-related peptide mRNA) in dorsal root ganglia from spontaneously hypertensive and Wistar-Kyoto control rats. Dorsal root ganglia neuronal cell bodies are a prominent site of calcitonin gene-related peptide synthesis and send axons to peripheral blood vessels and central spinal cord sites (laminae I/II). After normalization of calcitonin gene-related peptide mRNA levels of 18S RNA, the calcitonin gene-related peptide mRNA/18S RNA ratio was significantly decreased approximately threefold in the spontaneously hypertensive rats compared with controls. This alteration in calcitonin gene-related peptide mRNA levels is specific for dorsal root ganglia, because no strain differences in calcitonin gene-related peptide mRNA content were detected in heart or brain.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:8505084 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8505084 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8505084 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8505084 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8505084 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8505084 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8505084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8505084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8505084 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8505084 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8505084 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8505084 | pubmed:issn | 0194-911X | lld:pubmed |
| pubmed-article:8505084 | pubmed:author | pubmed-author:DiPetteD JDJ | lld:pubmed |
| pubmed-article:8505084 | pubmed:author | pubmed-author:WestlundK NKN | lld:pubmed |
| pubmed-article:8505084 | pubmed:author | pubmed-author:SupowitS CSC | lld:pubmed |
| pubmed-article:8505084 | pubmed:author | pubmed-author:RamanaC VCV | lld:pubmed |
| pubmed-article:8505084 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8505084 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:8505084 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8505084 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8505084 | pubmed:pagination | 1010-4 | lld:pubmed |
| pubmed-article:8505084 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:meshHeading | pubmed-meshheading:8505084-... | lld:pubmed |
| pubmed-article:8505084 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8505084 | pubmed:articleTitle | Calcitonin gene-related peptide gene expression in the spontaneously hypertensive rat. | lld:pubmed |
| pubmed-article:8505084 | pubmed:affiliation | Department of Internal Medicine, University of Texas Medical Branch, Galveston 77555-0645. | lld:pubmed |
| pubmed-article:8505084 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8505084 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8505084 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8505084 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8505084 | lld:pubmed |
