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pubmed-article:8504398pubmed:abstractTextResults of cell culture and cytogenetic analysis (standard and fluorescent in situ hybridization, FISH) of two sporadic gastrinomas are reported. Maintenance of hormonal activity was assessed by detection of gastrin levels during the first 3 months in culture. Case 1 showed clonal aberrations consisting of two marker chromosomes: marker 1 is a large metacentric chromosome and marker 2 is a small acrocentric chromosome. Case 2 showed a constitutional polymorphism with chromosome 15p+ and a clone in the tumor cell culture with trisomy for chromosome 3. To our knowledge, this is the first cytogenetic report of sporadic gastrinomas (Zollinger-Ellison syndrome).lld:pubmed
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pubmed-article:8504398pubmed:pagination44-9lld:pubmed
pubmed-article:8504398pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8504398pubmed:year1993lld:pubmed
pubmed-article:8504398pubmed:articleTitleChromosomal aberrations in two sporadic gastrinomas.lld:pubmed
pubmed-article:8504398pubmed:affiliationCenter for Molecular Biology, Wayne State University, Detroit, MI.lld:pubmed
pubmed-article:8504398pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8504398pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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