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| pubmed-article:8500870 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:8500870 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:8500870 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8500870 | lifeskim:mentions | umls-concept:C0151317 | lld:lifeskim |
| pubmed-article:8500870 | lifeskim:mentions | umls-concept:C0040557 | lld:lifeskim |
| pubmed-article:8500870 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:8500870 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8500870 | pubmed:dateCreated | 1993-6-28 | lld:pubmed |
| pubmed-article:8500870 | pubmed:abstractText | Resistance against acute and chronic infection with Taxoplasma gondii in BALB/c and CBA/Ca mice was compared. Intraperitoneal inoculation of either 20, 40, or 80 cysts of the ME49 strain resulted in mortality rates in BALB/c mice of 12% (2 of 17), 50% (6 of 12), and 75% (9 of 12), respectively, within 3 weeks after infection (acute stage). There was no mortality in the CBA/Ca mice for any of the doses. In marked contrast, CBA/Ca mice were highly sensitive to chronic infection with developing toxoplasmic encephalitis; they began dying 2 months after infection with 10 cysts of the ME49 strain, and mortality reached 53% (16 of 30) by the sixth month postinfection. No mortality (0 of 20) was observed in the chronically infected BALB/c mice. CBA/Ca mice had markedly more cysts in their brains than BALB/c mice in the chronic stage. Severe inflammatory changes were observed only in the brains of CBA/Ca mice. Interestingly, in the acute stage (the first 3 weeks), numbers of cysts in the brains were significantly greater in CBA/Ca than BALB/c mice, whereas only BALB/c mice showed mortality in that time period. No inflammatory changes were observed in brains of BALB/c mice during the acute stage of the infection. Thus, resistance against chronic infection appears to be regulated by a mechanism(s) that is different from those conferring resistance against acute infection. There was no difference in gamma interferon levels in sera between CBA/Ca and BALB/c mice during the acute stage. However, during the chronic stage, only BALB/c mice had detectable levels of gamma interferon in their sera. | lld:pubmed |
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| pubmed-article:8500870 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8500870 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500870 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8500870 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8500870 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8500870 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:8500870 | pubmed:author | pubmed-author:SuzukiYY | lld:pubmed |
| pubmed-article:8500870 | pubmed:author | pubmed-author:RemingtonJ... | lld:pubmed |
| pubmed-article:8500870 | pubmed:author | pubmed-author:WongS YSY | lld:pubmed |
| pubmed-article:8500870 | pubmed:author | pubmed-author:ConleyF KFK | lld:pubmed |
| pubmed-article:8500870 | pubmed:author | pubmed-author:OrellanaM AMA | lld:pubmed |
| pubmed-article:8500870 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8500870 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:8500870 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8500870 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8500870 | pubmed:pagination | 2284-8 | lld:pubmed |
| pubmed-article:8500870 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8500870 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8500870 | pubmed:articleTitle | Susceptibility to chronic infection with Toxoplasma gondii does not correlate with susceptibility to acute infection in mice. | lld:pubmed |
| pubmed-article:8500870 | pubmed:affiliation | Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:8500870 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8500870 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8500870 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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