| pubmed-article:8500558 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8500558 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8500558 | lifeskim:mentions | umls-concept:C0035298 | lld:lifeskim |
| pubmed-article:8500558 | lifeskim:mentions | umls-concept:C0004793 | lld:lifeskim |
| pubmed-article:8500558 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
| pubmed-article:8500558 | lifeskim:mentions | umls-concept:C0140116 | lld:lifeskim |
| pubmed-article:8500558 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
| pubmed-article:8500558 | lifeskim:mentions | umls-concept:C1419326 | lld:lifeskim |
| pubmed-article:8500558 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:8500558 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:8500558 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:8500558 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8500558 | pubmed:dateCreated | 1993-6-29 | lld:pubmed |
| pubmed-article:8500558 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:abstractText | In the process of photoreceptor signal transduction, light initiates an enzymatic cascade that leads to hydrolysis of cyclic GMP (cGMP) and closure of cGMP-gated sodium-calcium channels resulting in photoreceptor hyperpolarization. Recoverin is a calcium-binding protein that is thought to reverse the effects of light on cGMP levels by activating guanylate cyclase. Guanylate cyclase produces cGMP to overcome the cGMP-hydrolysing effect of phosphodiesterase, and reopens the sodium-calcium channels in photoreceptor outer segments. We have cloned and sequenced a cDNA encoding recoverin in human retina. The human nucleotide sequence is 88% identical to the bovine sequence, and contains a 600-base pair (bp) open reading frame encoding 200 amino acids. In situ hybridization of cultured Y79 human retinoblastoma cells with a radioactive recoverin cDNA probe showed intense, specific labeling of the cytoplasm, indicating the presence of mRNA encoding recoverin. Direct sequencing of a Y79 retinoblastoma cDNA polymerase chain reaction (PCR) product confirmed the presence of recoverin in this human cell line. | lld:pubmed |
| pubmed-article:8500558 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8500558 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8500558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8500558 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8500558 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8500558 | pubmed:issn | 0014-4835 | lld:pubmed |
| pubmed-article:8500558 | pubmed:author | pubmed-author:WiechmannA... | lld:pubmed |
| pubmed-article:8500558 | pubmed:author | pubmed-author:HammarbackJ... | lld:pubmed |
| pubmed-article:8500558 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8500558 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:8500558 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8500558 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8500558 | pubmed:pagination | 463-70 | lld:pubmed |
| pubmed-article:8500558 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:meshHeading | pubmed-meshheading:8500558-... | lld:pubmed |
| pubmed-article:8500558 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8500558 | pubmed:articleTitle | Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina. | lld:pubmed |
| pubmed-article:8500558 | pubmed:affiliation | Department of Neurobiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC. | lld:pubmed |
| pubmed-article:8500558 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8500558 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:5957 | entrezgene:pubmed | pubmed-article:8500558 | lld:entrezgene |
| entrez-gene:140936 | entrezgene:pubmed | pubmed-article:8500558 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8500558 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8500558 | lld:pubmed |
