| pubmed-article:8497872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8497872 | lifeskim:mentions | umls-concept:C0332835 | lld:lifeskim |
| pubmed-article:8497872 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:8497872 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:8497872 | lifeskim:mentions | umls-concept:C0231174 | lld:lifeskim |
| pubmed-article:8497872 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8497872 | pubmed:dateCreated | 1993-6-21 | lld:pubmed |
| pubmed-article:8497872 | pubmed:abstractText | The causes of failure were studied for 1386 cadaver kidney transplants shared through the UNOS 6-antigen match program from November 1987 to February 1992. The one-year graft survival for 1004 HLA-matched first cadaver transplants was 88% compared with 90% for parent donor and 78% for 22,188 HLA-mismatched first cadaveric donors reported to the UNOS Scientific Renal Transplant Registry. The cause of graft loss was immunological in 55% of HLA-mismatched cadaver kidney failures, whereas only 39% of the HLA-matched graft failures were immunological. The fraction of immunological failures in HLA-matched first transplant recipients younger than age 17 was 57% and decreased with increasing age to 14% for recipients older than age 60. Death with a functioning graft accounted for 50% of failures in the older age group. Sensitization was associated with an increased incidence of immunological failures in matched first graft recipients from 36% in nonsensitized to 53% in broadly sensitized patients, and 55% of failures were immunological in second graft recipients compared with 39% in first transplants. Some immunological failures may have been due to tissue typing, since only 18% of failures in kidneys with well-defined HLA antigens were immunological, whereas 44% of kidneys matched with more difficult HLA antigens were lost due to immunological causes. The results indicate that phenotypically identical cadaver renal transplants have a reduced rate of immunological failures. As the accuracy of this tissue typing for the more difficult HLA antigens improves, immunological failures in this group of transplants will decline even further. | lld:pubmed |
| pubmed-article:8497872 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8497872 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8497872 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8497872 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8497872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8497872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8497872 | pubmed:month | May | lld:pubmed |
| pubmed-article:8497872 | pubmed:issn | 0041-1337 | lld:pubmed |
| pubmed-article:8497872 | pubmed:author | pubmed-author:TerasakiP IPI | lld:pubmed |
| pubmed-article:8497872 | pubmed:author | pubmed-author:CeckaJ MJM | lld:pubmed |
| pubmed-article:8497872 | pubmed:author | pubmed-author:TakemotoSS | lld:pubmed |
| pubmed-article:8497872 | pubmed:author | pubmed-author:GjertsonD WDW | lld:pubmed |
| pubmed-article:8497872 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8497872 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:8497872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8497872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8497872 | pubmed:pagination | 1005-8 | lld:pubmed |
| pubmed-article:8497872 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8497872 | pubmed:meshHeading | pubmed-meshheading:8497872-... | lld:pubmed |
| pubmed-article:8497872 | pubmed:meshHeading | pubmed-meshheading:8497872-... | lld:pubmed |
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| pubmed-article:8497872 | pubmed:meshHeading | pubmed-meshheading:8497872-... | lld:pubmed |
| pubmed-article:8497872 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8497872 | pubmed:articleTitle | Six-antigen-matched transplants. Causes of failure. | lld:pubmed |
| pubmed-article:8497872 | pubmed:affiliation | Tissue Typing Laboratory, University of California, Los Angeles 90024. | lld:pubmed |
| pubmed-article:8497872 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8497872 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
