| pubmed-article:8495429 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C0205329 | lld:lifeskim |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C0425245 | lld:lifeskim |
| pubmed-article:8495429 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:8495429 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8495429 | pubmed:dateCreated | 1993-6-21 | lld:pubmed |
| pubmed-article:8495429 | pubmed:abstractText | The high mobility group (HMG) proteins I and Y are well characterized nonhistone chromosomal proteins which bind to A.T-rich regions of DNA, and may regulate gene expression and/or DNA replication. We utilized a series of mouse mammary epithelial preneoplastic and tumor cell lines to explore the relationship between neoplastic transformation and HMG-I(Y) gene expression. The cell lines used in this study were originally derived from a single hyperplastic outgrowth, and exhibit a distinct gradient of preneoplastic to highly metastatic transformation states. We measured the levels of HMG-I(Y) gene expression in these cell lines during the different phases of cell growth in culture. At both subconfluent and confluent cell densities, elevated levels of HMG-I(Y) mRNA were directly correlated with the relative degree of neoplastic transformation and metastatic progression of these cells. HMG-I(Y) mRNA levels were always highest in proliferating cells. However, the differences in HMG-I(Y) gene expression between the cell lines were greatest at confluent cell density, when the cells were not actively proliferating. HMG-I(Y) mRNA was detectable in normal primary mouse mammary epithelium proliferating in culture. However, the amount was much less than that measured in the cell lines, indicating that elevated HMG-I(Y) gene expression was also directly correlated with the conversion of normal mammary epithelium to the preneoplastic immortalized state. Southern blot analysis showed that alterations in HMG-I(Y) loci are also associated with the preneoplastic to neoplastic conversion of these cell lines, and this change may involve a gene conversion event between two different HMG-I(Y) loci. These results indicate that there is a strong correlation between elevated HMG-I(Y) gene expression and the progressive transformation of mouse mammary epithelial cells. | lld:pubmed |
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| pubmed-article:8495429 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8495429 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8495429 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8495429 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8495429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8495429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8495429 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8495429 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8495429 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:8495429 | pubmed:author | pubmed-author:ReevesRR | lld:pubmed |
| pubmed-article:8495429 | pubmed:author | pubmed-author:HosickH LHL | lld:pubmed |
| pubmed-article:8495429 | pubmed:author | pubmed-author:FanH NHN | lld:pubmed |
| pubmed-article:8495429 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8495429 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8495429 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:8495429 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8495429 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8495429 | pubmed:pagination | 2655-60 | lld:pubmed |
| pubmed-article:8495429 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8495429 | pubmed:meshHeading | pubmed-meshheading:8495429-... | lld:pubmed |
| pubmed-article:8495429 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8495429 | pubmed:articleTitle | Elevated high mobility group-I(Y) gene expression is associated with progressive transformation of mouse mammary epithelial cells. | lld:pubmed |
| pubmed-article:8495429 | pubmed:affiliation | Department of Zoology, Washington State University, Pullman 99164-4236. | lld:pubmed |
| pubmed-article:8495429 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8495429 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8495429 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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