| pubmed-article:8482839 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8482839 | lifeskim:mentions | umls-concept:C0011065 | lld:lifeskim |
| pubmed-article:8482839 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:8482839 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8482839 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:8482839 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:8482839 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8482839 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8482839 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8482839 | pubmed:dateCreated | 1993-6-3 | lld:pubmed |
| pubmed-article:8482839 | pubmed:abstractText | Signaling via the CD3/TCR complex induces programmed cell death (apoptosis) in immature thymocytes and transformed T lymphocytes (hybridomas or leukemic cells). Accumulating evidence indicates, however, that apoptosis can be triggered also in mature peripheral T cells. Here we show that a significant fraction of cells of a given IL-2-dependent TCR-alpha beta + clone or polyclonal short term line is killed when cultured for 20 h in the presence of PHA, anti-CD3 (OKT3), or anti-TCR (BMA031) mAb. Apoptosis can be triggered by these stimuli in CD4+, CD8+, and CD4-CD8- (double-negative) TCR-alpha beta+ clones. Activation-driven cell death (as quantified by propidium iodide staining and FACS analysis) is associated with fragmentation of DNA into oligonucleosomal bands of approximately 200 bp. Although freshly isolated peripheral blood T cells are largely resistant to apoptosis, the sensitivity to anti-CD3/TCR mAb or PHA-triggered cell death gradually increases upon activation and IL-2-dependent culture of T cells, and reaches a plateau level after 15 to 20 days. These data indicate that stimuli that activate resting T cells initiate death by apoptosis in activated T cells. The implications of these results for the regulation of cellular immune responses and the establishment of peripheral tolerance will be discussed. | lld:pubmed |
| pubmed-article:8482839 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8482839 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8482839 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8482839 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8482839 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8482839 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8482839 | pubmed:month | May | lld:pubmed |
| pubmed-article:8482839 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8482839 | pubmed:author | pubmed-author:KabelitzDD | lld:pubmed |
| pubmed-article:8482839 | pubmed:author | pubmed-author:WesselborgSS | lld:pubmed |
| pubmed-article:8482839 | pubmed:author | pubmed-author:JanssenOO | lld:pubmed |
| pubmed-article:8482839 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8482839 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8482839 | pubmed:volume | 150 | lld:pubmed |
| pubmed-article:8482839 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8482839 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8482839 | pubmed:pagination | 4338-45 | lld:pubmed |
| pubmed-article:8482839 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8482839 | pubmed:meshHeading | pubmed-meshheading:8482839-... | lld:pubmed |
| pubmed-article:8482839 | pubmed:meshHeading | pubmed-meshheading:8482839-... | lld:pubmed |
| pubmed-article:8482839 | pubmed:meshHeading | pubmed-meshheading:8482839-... | lld:pubmed |
| pubmed-article:8482839 | pubmed:meshHeading | pubmed-meshheading:8482839-... | lld:pubmed |
| pubmed-article:8482839 | pubmed:meshHeading | pubmed-meshheading:8482839-... | lld:pubmed |
| pubmed-article:8482839 | pubmed:meshHeading | pubmed-meshheading:8482839-... | lld:pubmed |
| pubmed-article:8482839 | pubmed:meshHeading | pubmed-meshheading:8482839-... | lld:pubmed |
| pubmed-article:8482839 | pubmed:meshHeading | pubmed-meshheading:8482839-... | lld:pubmed |
| pubmed-article:8482839 | pubmed:meshHeading | pubmed-meshheading:8482839-... | lld:pubmed |
| pubmed-article:8482839 | pubmed:meshHeading | pubmed-meshheading:8482839-... | lld:pubmed |
| pubmed-article:8482839 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8482839 | pubmed:articleTitle | Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells. | lld:pubmed |
| pubmed-article:8482839 | pubmed:affiliation | Institute of Immunology, University of Heidelberg, Germany. | lld:pubmed |
| pubmed-article:8482839 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8482839 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8482839 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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