| pubmed-article:8478093 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8478093 | lifeskim:mentions | umls-concept:C0026447 | lld:lifeskim |
| pubmed-article:8478093 | lifeskim:mentions | umls-concept:C1265472 | lld:lifeskim |
| pubmed-article:8478093 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:8478093 | lifeskim:mentions | umls-concept:C0036825 | lld:lifeskim |
| pubmed-article:8478093 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:8478093 | lifeskim:mentions | umls-concept:C0032150 | lld:lifeskim |
| pubmed-article:8478093 | lifeskim:mentions | umls-concept:C1418531 | lld:lifeskim |
| pubmed-article:8478093 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8478093 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8478093 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:8478093 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8478093 | pubmed:dateCreated | 1993-5-24 | lld:pubmed |
| pubmed-article:8478093 | pubmed:abstractText | We describe the third of three vaccination trials of Panamanian Aotus monkeys with a recombinant blood-stage antigen derived from the malaria parasite Plasmodium falciparum. Immunization was performed with an N-terminal region of the SERA antigen (serine repeat antigen protein), SERA 1, that contains a 262-amino-acid fragment including amino acids 24 to 285 of the 989-amino-acid SERA protein. Vaccinations were carried out with the recombinant protein mixed with either Freund's, MF75.2, or MF59.2 adjuvant. A control group that did not receive SERA 1 but only MF75.2 adjuvant was included. Monkeys vaccinated with the antigen MF59.2 mixture produced low anti-SERA 1 titers and were not protected. Monkeys vaccinated with antigen and Freund's adjuvant had, in general, a higher average anti-SERA 1 titer (107,278) than did monkeys immunized with SERA 1 and MF75.2 (40, 143), yet monkeys in both groups were well protected. Monkeys that received only MF75.2 developed neither detectable anti-SERA 1 nor anti-P. falciparum antibodies prior to or 10 days after parasite challenge, yet were apparently protected against infection. Monkeys vaccinated with either SERA 1 and Freund's, SERA 1 and MF75.2, or MF75.2 alone and that had been challenged but did not develop a countable parasitemia were treated with a curative dose of mefloquine 100 days after parasite challenge and then rechallenged 40 days later. None of the five rechallenged monkeys that had originally received SERA 1 and Freund's developed a countable parasitemia. Only one of five rechallenged monkeys that originally received SERA 1 and MF75.2 developed a high countable parasitemia, while two animals developed a barely countable parasitemia. Four of the rechallenged monkeys that had originally received only MF75.2 developed a moderate to high countable parasitemia. The results indicate that vaccination with SERA 1 and either Freund's or MF75.2 adjuvant provides protection and vaccination with MF75.2 alone can provide a temporary protection unrelated to the induction of anti-SERA 1 or antimalarial antibodies. | lld:pubmed |
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| pubmed-article:8478093 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8478093 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8478093 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8478093 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8478093 | pubmed:month | May | lld:pubmed |
| pubmed-article:8478093 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:8478093 | pubmed:author | pubmed-author:BarrP JPJ | lld:pubmed |
| pubmed-article:8478093 | pubmed:author | pubmed-author:InselburgJJ | lld:pubmed |
| pubmed-article:8478093 | pubmed:author | pubmed-author:BathurstI CIC | lld:pubmed |
| pubmed-article:8478093 | pubmed:author | pubmed-author:KansoponJJ | lld:pubmed |
| pubmed-article:8478093 | pubmed:author | pubmed-author:RossanRR | lld:pubmed |
| pubmed-article:8478093 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8478093 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:8478093 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8478093 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8478093 | pubmed:pagination | 2048-52 | lld:pubmed |
| pubmed-article:8478093 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8478093 | pubmed:meshHeading | pubmed-meshheading:8478093-... | lld:pubmed |
| pubmed-article:8478093 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8478093 | pubmed:articleTitle | Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: further studies using SERA 1 and MF75.2 adjuvant. | lld:pubmed |
| pubmed-article:8478093 | pubmed:affiliation | Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755-3842. | lld:pubmed |
| pubmed-article:8478093 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8478093 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8478093 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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