| pubmed-article:8478060 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8478060 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8478060 | lifeskim:mentions | umls-concept:C0006304 | lld:lifeskim |
| pubmed-article:8478060 | lifeskim:mentions | umls-concept:C0560175 | lld:lifeskim |
| pubmed-article:8478060 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:8478060 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:8478060 | lifeskim:mentions | umls-concept:C1706209 | lld:lifeskim |
| pubmed-article:8478060 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8478060 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8478060 | pubmed:dateCreated | 1993-5-24 | lld:pubmed |
| pubmed-article:8478060 | pubmed:abstractText | In order to determine the carrier nature of lipopolysaccharide from Brucella abortus (LPS-BA) in evoking humoral responses, normal and immunodeficient mice were immunized with trinitrophenyl (TNP)-conjugated LPS-BA (TNP-LPS-BA) and the responses were compared with those to known T-dependent and T-independent antigens. TNP-LPS-BA, like T-independent type 1 (TI-1) antigens such as TNP-BA and TNP-LPS from Escherichia coli (TNP-LPS-EC), generated anti-TNP responses in BALB/c, athymic BALB/c nu/nu, and CBA/N mice. In contrast, N-2,4-dinitrophenyl-beta-alanylglycylglycyl-substituted keyhole limpet hemocyanin, a typical T-dependent antigen, was not immunogenic in athymic mice, and TNP-Ficoll (T-independent type 2) was ineffective in eliciting humoral responses in CBA/N mice. These results indicate that LPS from B. abortus acts as a TI-1 carrier in generating antibody responses. In C3H/HeJ mice, TNP-LPS-BA generated higher-titer immunoglobulin G1 (IgG1), IgG2a, and IgG2b anti-TNP antibodies than TNP-LPS-EC. Compared with those from BALB/c mice, pure resting B cells isolated from C3H/HeJ mice exhibited a 30-fold lower proliferative response to LPS-EC, whereas the LPS-BA response was reduced to a lesser extent (5-fold). This suggests that the disparity observed in antibody titers was due to different abilities of LPS from B. abortus and E. coli to stimulate C3H/HeJ B cells. The ability of LPS from B. abortus to act as a carrier in generating humoral immune responses indicates that LPS-BA can be substituted for whole B. abortus organisms in vaccine development. | lld:pubmed |
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| pubmed-article:8478060 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8478060 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8478060 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8478060 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8478060 | pubmed:month | May | lld:pubmed |
| pubmed-article:8478060 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:8478060 | pubmed:author | pubmed-author:HoffmanTT | lld:pubmed |
| pubmed-article:8478060 | pubmed:author | pubmed-author:AngusR DRD | lld:pubmed |
| pubmed-article:8478060 | pubmed:author | pubmed-author:GoldingBB | lld:pubmed |
| pubmed-article:8478060 | pubmed:author | pubmed-author:InmanJJ | lld:pubmed |
| pubmed-article:8478060 | pubmed:author | pubmed-author:BettsMM | lld:pubmed |
| pubmed-article:8478060 | pubmed:author | pubmed-author:BrunswickMM | lld:pubmed |
| pubmed-article:8478060 | pubmed:author | pubmed-author:BeiningPP | lld:pubmed |
| pubmed-article:8478060 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8478060 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:8478060 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8478060 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8478060 | pubmed:pagination | 1722-9 | lld:pubmed |
| pubmed-article:8478060 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8478060 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8478060 | pubmed:articleTitle | Lipopolysaccharide from Brucella abortus behaves as a T-cell-independent type 1 carrier in murine antigen-specific antibody responses. | lld:pubmed |
| pubmed-article:8478060 | pubmed:affiliation | Laboratory of Cell Biology, U.S. Food and Drug Administration, Bethesda, Maryland. | lld:pubmed |
| pubmed-article:8478060 | pubmed:publicationType | Journal Article | lld:pubmed |
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