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| pubmed-article:8474170 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:8474170 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:8474170 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:8474170 | lifeskim:mentions | umls-concept:C1704973 | lld:lifeskim |
| pubmed-article:8474170 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:8474170 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:8474170 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8474170 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:8474170 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8474170 | pubmed:dateCreated | 1993-5-17 | lld:pubmed |
| pubmed-article:8474170 | pubmed:abstractText | Flock house virus is a small insect virus with a bipartite RNA genome consisting of RNA1 and RNA2. RNA3 is a subgenomic element encoded by RNA1, the genomic segment required for viral RNA synthesis (T. M. Gallagher, P. D. Friesen, and R. R. Rueckert, J. Virol. 46:481-489, 1983). Synthesis of RNA3 is strongly inhibited by RNA2, the gene for viral coat protein. Evidence that coat protein is not the regulatory element was obtained by using a defective interfering RNA2 which was messenger inactive. It was also found that RNA2 selectively down-regulated synthesis of positive-strand RNA3 but not of its complementary negative strand. cDNA-generated RNA2 transcripts, carrying four extra nonviral bases at the 3' end, failed to repress synthesis of RNA3 but recovered this activity after a single passage in Drosophila cells in the presence of RNA1, suggesting that down-regulation of RNA3 synthesis is controlled by competition with RNA2 for viral replicase. | lld:pubmed |
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| pubmed-article:8474170 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8474170 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8474170 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8474170 | pubmed:month | May | lld:pubmed |
| pubmed-article:8474170 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:8474170 | pubmed:author | pubmed-author:RueckertR RRR | lld:pubmed |
| pubmed-article:8474170 | pubmed:author | pubmed-author:ZhongWW | lld:pubmed |
| pubmed-article:8474170 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8474170 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:8474170 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8474170 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8474170 | pubmed:pagination | 2716-22 | lld:pubmed |
| pubmed-article:8474170 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
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| pubmed-article:8474170 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8474170 | pubmed:articleTitle | Flock house virus: down-regulation of subgenomic RNA3 synthesis does not involve coat protein and is targeted to synthesis of its positive strand. | lld:pubmed |
| pubmed-article:8474170 | pubmed:affiliation | Institute for Molecular Virology, University of Wisconsin-Madison 53706-1596. | lld:pubmed |
| pubmed-article:8474170 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8474170 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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