| pubmed-article:8471424 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8471424 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8471424 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8471424 | lifeskim:mentions | umls-concept:C0035412 | lld:lifeskim |
| pubmed-article:8471424 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:8471424 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8471424 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:8471424 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8471424 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:8471424 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8471424 | pubmed:dateCreated | 1993-5-14 | lld:pubmed |
| pubmed-article:8471424 | pubmed:abstractText | The effects of dexamethasone, a synthetic glucocorticoid, and of N,N-dimethylformamide on in vitro growth and differentiation and on proto-oncogene expression of human rhabdomyosarcoma cells were studied. RD/18 clone cells (derived from the embryonal rhabdomyosarcoma cell line RD) treated with 100 nM dexamethasone showed an almost complete block of differentiation: about 5% myosin-positive cells were observed after 2 weeks of culture in dexamethasone-supplemented differentiation medium, compared to 20% of untreated cultures. Dexamethasone also induced a 20-30% growth inhibition and a more flattened morphology. The treatment with N,N-dimethylformamide induced a significantly increased proportion of myosin-positive cells (reaching about 30%) and a 40% growth inhibition. Induction of differentiation inversely correlated with the levels of c-myc proto-oncogene expression: after a 2 week culture dexamethasone-treated cells showed the highest c-myc expression and N,N-dimethylformamide-treated cells the lowest. Culture conditions per se down-modulated c-erbB1 and up-regulated c-jun expression, with no relationship to the differentiation pattern. Other proto-oncogenes were not expressed (c-sis, N-myc, c-mos, c-myb) or were not modulated (c-fos, c-raf). Therefore dexamethasone and N,N-dimethylformamide, both causing a decreased growth rate, showed opposing actions on myogenic differentiation and on c-myc proto-oncogene expression of human rhabdomyosarcoma cells. | lld:pubmed |
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| pubmed-article:8471424 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8471424 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471424 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8471424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471424 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8471424 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8471424 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:8471424 | pubmed:author | pubmed-author:NicolettiGG | lld:pubmed |
| pubmed-article:8471424 | pubmed:author | pubmed-author:D'AndreaEE | lld:pubmed |
| pubmed-article:8471424 | pubmed:author | pubmed-author:NanniPP | lld:pubmed |
| pubmed-article:8471424 | pubmed:author | pubmed-author:De GiovanniCC | lld:pubmed |
| pubmed-article:8471424 | pubmed:author | pubmed-author:LolliniP LPL | lld:pubmed |
| pubmed-article:8471424 | pubmed:author | pubmed-author:LanduzziLL | lld:pubmed |
| pubmed-article:8471424 | pubmed:author | pubmed-author:DolcettiRR | lld:pubmed |
| pubmed-article:8471424 | pubmed:author | pubmed-author:ScotlandKK | lld:pubmed |
| pubmed-article:8471424 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8471424 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:8471424 | pubmed:geneSymbol | c-sis | lld:pubmed |
| pubmed-article:8471424 | pubmed:geneSymbol | c-mos | lld:pubmed |
| pubmed-article:8471424 | pubmed:geneSymbol | c-myb | lld:pubmed |
| pubmed-article:8471424 | pubmed:geneSymbol | c-myc | lld:pubmed |
| pubmed-article:8471424 | pubmed:geneSymbol | N-myc | lld:pubmed |
| pubmed-article:8471424 | pubmed:geneSymbol | c-jun | lld:pubmed |
| pubmed-article:8471424 | pubmed:geneSymbol | c-erbB1 | lld:pubmed |
| pubmed-article:8471424 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8471424 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8471424 | pubmed:pagination | 674-9 | lld:pubmed |
| pubmed-article:8471424 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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