| pubmed-article:8471415 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8471415 | lifeskim:mentions | umls-concept:C0681876 | lld:lifeskim |
| pubmed-article:8471415 | lifeskim:mentions | umls-concept:C0020934 | lld:lifeskim |
| pubmed-article:8471415 | lifeskim:mentions | umls-concept:C0030011 | lld:lifeskim |
| pubmed-article:8471415 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8471415 | pubmed:dateCreated | 1993-5-14 | lld:pubmed |
| pubmed-article:8471415 | pubmed:abstractText | The metabolism of imipramine was investigated in 106 healthy volunteers, all having a sparteine metabolic ratio (MR) of 0.2-0.5 and hence classified as extensive metabolisers. Each subject was given a single oral dose of 25 mg imipramine hydrochloride and blood for assays of imipramine and metabolites was collected 3 h thereafter. The desipramine/imipramine ratio and the 2-OH-desipramine/2-OH-imipramine ratio in plasma, reflecting the demethylation of imipramine and 2-OH-imipramine, respectively, showed significant negative correlations with the mephenytoin S/R ratio (Spearman rank correlation) (rs): -0.46, P < 0.00002 and -0.41, P < 0.00002). No correlations were found between the 2-hydroxylation of imipramine or desipramine and the mephenytoin S/R. These findings confirm those of an earlier panel study showing that the demethylation of imipramine and 2-OH-imipramine cosegregates in part with the mephenytoin oxidation polymorphism. | lld:pubmed |
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| pubmed-article:8471415 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8471415 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471415 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8471415 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8471415 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8471415 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8471415 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8471415 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:8471415 | pubmed:author | pubmed-author:GramL FLF | lld:pubmed |
| pubmed-article:8471415 | pubmed:author | pubmed-author:BrøsenKK | lld:pubmed |
| pubmed-article:8471415 | pubmed:author | pubmed-author:SkjelboEE | lld:pubmed |
| pubmed-article:8471415 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8471415 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:8471415 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8471415 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8471415 | pubmed:pagination | 331-4 | lld:pubmed |
| pubmed-article:8471415 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8471415 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8471415 | pubmed:articleTitle | The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio). A population study. | lld:pubmed |
| pubmed-article:8471415 | pubmed:affiliation | Department of Clinical Pharmacology, IMB, Odense University, Denmark. | lld:pubmed |
| pubmed-article:8471415 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8471415 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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