| pubmed-article:8460162 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8460162 | lifeskim:mentions | umls-concept:C0019644 | lld:lifeskim |
| pubmed-article:8460162 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:8460162 | lifeskim:mentions | umls-concept:C0042333 | lld:lifeskim |
| pubmed-article:8460162 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:8460162 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:8460162 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:8460162 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:8460162 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:8460162 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8460162 | pubmed:dateCreated | 1993-4-23 | lld:pubmed |
| pubmed-article:8460162 | pubmed:abstractText | The chromatin of most cell types contains several different sequence variants of histone H1. The functional role of this heterogeneity is not known. In the larval tissues of the midge, Chironomus thummi, there are H1 variants of two types. H1 II-1, H1 II-2, and H1 III-1 have similar amino acid sequences and appear uniformly distributed in polytene interphase chromosomes. The total number of gene copies per genome for this type of H1 histones is about 40 in C. th. thummi and 50-60 in C. th. piger. In contrast, histone H1 I-1 is encoded by a single copy gene in C. th. thummi and by two to four genes in C. th. piger. It has a divergent structure and is found only in a limited number of condensed chromosome sites. The N-terminal domain of H1 I-1 contains an insertion that is lacking in the other H1 variants and that is part of a variant-specific bipartite sequence Lys-Ala-Pro-Lys-Ala-Pro-Xaa10-Lys-Val-Ala in front of the conserved central domain. N-terminal peptides of H1 I-1 including this motif, in contrast to the homologous peptide from H1 II-1, competed with the drug Hoechst 33258 for binding to the minor groove of the DNA double helix. Repeats of the sequence Lys-Ala-Pro are also present at the same distance from the conserved central domain, in a single H1 variant of a nematode and of a green alga. The motif could interact with linker DNA in intranuclear targeting or packaging a condensed subtype of chromatin, or both. | lld:pubmed |
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| pubmed-article:8460162 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8460162 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8460162 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8460162 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8460162 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8460162 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8460162 | pubmed:author | pubmed-author:SchulzeBB | lld:pubmed |
| pubmed-article:8460162 | pubmed:author | pubmed-author:ZechelKK | lld:pubmed |
| pubmed-article:8460162 | pubmed:author | pubmed-author:SchulzeEE | lld:pubmed |
| pubmed-article:8460162 | pubmed:author | pubmed-author:GrossbachUU | lld:pubmed |
| pubmed-article:8460162 | pubmed:author | pubmed-author:SchmidtE RER | lld:pubmed |
| pubmed-article:8460162 | pubmed:author | pubmed-author:TrieschmannLL | lld:pubmed |
| pubmed-article:8460162 | pubmed:author | pubmed-author:PitzelSS | lld:pubmed |
| pubmed-article:8460162 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8460162 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8460162 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8460162 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8460162 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8460162 | pubmed:pagination | 2481-5 | lld:pubmed |
| pubmed-article:8460162 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8460162 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8460162 | pubmed:articleTitle | Structural and functional differences between histone H1 sequence variants with differential intranuclear distribution. | lld:pubmed |
| pubmed-article:8460162 | pubmed:affiliation | Third Department of Zoology-Developmental Biology, University of Göttingen, Federal Republic of Germany. | lld:pubmed |
| pubmed-article:8460162 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8460162 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8460162 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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