| pubmed-article:8458598 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8458598 | lifeskim:mentions | umls-concept:C1708335 | lld:lifeskim |
| pubmed-article:8458598 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:8458598 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:8458598 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:8458598 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:8458598 | lifeskim:mentions | umls-concept:C0232478 | lld:lifeskim |
| pubmed-article:8458598 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8458598 | pubmed:dateCreated | 1993-4-27 | lld:pubmed |
| pubmed-article:8458598 | pubmed:abstractText | L-Dopa is converted to dopamine by aromatic-L-amino acid decarboxylase (AADC). In the kidney, proximal tubular epithelial cells are rich in AADC and urinary free dopamine excretion is a marker for endorenal extraneuronal dopamine synthesis. The urinary free dopamine excretion was analysed in a double-blind cross-over study after oral ingestion of L-Dopa or a placebo in five healthy volunteers. The drug ingestions were separated by one week's wash-out. Since in a preliminary study, two volunteers ingesting a single L-Dopa dose of 500 mg with breakfast experienced nausea, the five volunteers of the present study were given 300 mg L-Dopa (50 mg at 9 am with breakfast, 100 mg before lunch and 150 mg before dinner) without any adverse effects. L-Dopa induced an increase in 24-h urinary dopamine excretion (HPLC with electrochemical detection). Free urinary dopamine (1900 micrograms/24 h) accounted for 0.8% of the daily oral L-Dopa dose and represented 10% of total urinary dopamine excretion. L-Dopa treatment had no significant effect on mean ambulatory arterial blood pressure and heart rate measured from 9 am to 6 pm (Spacelabs) or on 24 h urinary water and sodium excretion. | lld:pubmed |
| pubmed-article:8458598 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8458598 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458598 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8458598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458598 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8458598 | pubmed:issn | 0767-3981 | lld:pubmed |
| pubmed-article:8458598 | pubmed:author | pubmed-author:ImbsJ LJL | lld:pubmed |
| pubmed-article:8458598 | pubmed:author | pubmed-author:GrimmAA | lld:pubmed |
| pubmed-article:8458598 | pubmed:author | pubmed-author:StephanDD | lld:pubmed |
| pubmed-article:8458598 | pubmed:author | pubmed-author:BarthelmebsMM | lld:pubmed |
| pubmed-article:8458598 | pubmed:author | pubmed-author:MbouPP | lld:pubmed |
| pubmed-article:8458598 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8458598 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:8458598 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8458598 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8458598 | pubmed:pagination | 11-6 | lld:pubmed |
| pubmed-article:8458598 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:meshHeading | pubmed-meshheading:8458598-... | lld:pubmed |
| pubmed-article:8458598 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8458598 | pubmed:articleTitle | Renal dopamine excretion in healthy volunteers after oral ingestion of L-dopa. | lld:pubmed |
| pubmed-article:8458598 | pubmed:affiliation | Institut de Pharmacologie, URA DO589 CNRS, Faculté de Médecine, Strasbourg, France. | lld:pubmed |
| pubmed-article:8458598 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8458598 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:8458598 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
