| pubmed-article:8458396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8458396 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:8458396 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:8458396 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:8458396 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8458396 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:8458396 | lifeskim:mentions | umls-concept:C0439834 | lld:lifeskim |
| pubmed-article:8458396 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8458396 | pubmed:dateCreated | 1993-4-29 | lld:pubmed |
| pubmed-article:8458396 | pubmed:abstractText | The effect of cholecystokinin octapeptide (CCK-8) was examined in guinea-pig celiac ganglion (CG) neurons in primary culture using standard intracellular recording techniques. Sulfated CCK-8 (CCK-8S; 1 microM) evoked slow depolarizing responses in 94% of CG neurons tested. In contrast, membrane potential was not affected by nonsulfated CCK-8 (CCK-8NS; 1 microM), CCK tetrapeptide (CCK-4; 1 microM), or gastrin (1 microM). The selective CCKA receptor antagonist L 364,718 potently inhibited CCK-8S-induced slow depolarizations (IC50 2.9 pM). In contrast, the selective CCKB receptor antagonist L 365,260 was a weak inhibitor of CCK-8S-induced slow depolarizations (IC50 1.3 microM). The depolarizing responses to CCK-8S were associated with an average increase in cell input resistance of 61%. Single electrode voltage clamp experiments indicated that CCK-8S-induced depolarizations were associated with a slow inward shift in holding current. Thus, the present findings indicate that guinea-pig cultured CG neurons are endowed with excitatory CCKA receptors the activation of which elicits a decrease in membrane conductance, thereby resulting in slow depolarizations. | lld:pubmed |
| pubmed-article:8458396 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8458396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8458396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8458396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8458396 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8458396 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:8458396 | pubmed:author | pubmed-author:KreulenD LDL | lld:pubmed |
| pubmed-article:8458396 | pubmed:author | pubmed-author:KnoperS RSR | lld:pubmed |
| pubmed-article:8458396 | pubmed:author | pubmed-author:MeehanA GAG | lld:pubmed |
| pubmed-article:8458396 | pubmed:author | pubmed-author:AnthonyT LTL | lld:pubmed |
| pubmed-article:8458396 | pubmed:author | pubmed-author:CogganJ SJS | lld:pubmed |
| pubmed-article:8458396 | pubmed:author | pubmed-author:PurnynSS | lld:pubmed |
| pubmed-article:8458396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8458396 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:8458396 | pubmed:volume | 232 | lld:pubmed |
| pubmed-article:8458396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8458396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8458396 | pubmed:pagination | 65-9 | lld:pubmed |
| pubmed-article:8458396 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:meshHeading | pubmed-meshheading:8458396-... | lld:pubmed |
| pubmed-article:8458396 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8458396 | pubmed:articleTitle | CCKA receptors mediate slow depolarizations in cultured mammalian sympathetic neurons. | lld:pubmed |
| pubmed-article:8458396 | pubmed:affiliation | Department of Pharmacology, College of Medicine, University of Arizona, Tucson 85724. | lld:pubmed |
| pubmed-article:8458396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8458396 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8458396 | lld:pubmed |
