| pubmed-article:8454641 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C1314972 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C0061688 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C0002518 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C0237497 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C1624581 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C1527177 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C0185023 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C1947904 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C0441513 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C1999228 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C2825781 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:8454641 | lifeskim:mentions | umls-concept:C1293132 | lld:lifeskim |
| pubmed-article:8454641 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8454641 | pubmed:dateCreated | 1993-4-22 | lld:pubmed |
| pubmed-article:8454641 | pubmed:abstractText | Many membrane proteins are anchored to the cell surface through covalent attachment to a glycosyl-phosphatidylinositol (GPI) structure. The GPI anchor is added to proteins in the endoplasmic reticulum following recognition of a signal in the COOH terminus of the protein. We show that the GPI anchoring signal can be completely recreated by the synthetic polymer Ser3-Thr8-Leu14, but not Thr11-Leu14, inserted at the COOH terminus of a protein. This is consistent with previous reports that a small amino acid such as Ser, Gly, or Ala, but not Thr, is required at the GPI attachment site. Analysis of synthetic amino acid sequences established a basic three-part signal for GPI anchoring: a cleavage/attachment domain that requires small amino acids at the first (GPI anchor attachment) and third positions but with little specificity at the middle position, a spacer domain of approximately 8-12 amino acids, and a hydrophobic domain of at least 11 amino acids. The ability to design a totally synthetic GPI anchoring signal will allow precise probing of the fine structure of this signal. | lld:pubmed |
| pubmed-article:8454641 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8454641 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8454641 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8454641 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8454641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8454641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8454641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8454641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8454641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8454641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8454641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8454641 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8454641 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8454641 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8454641 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8454641 | pubmed:author | pubmed-author:LublinD MDM | lld:pubmed |
| pubmed-article:8454641 | pubmed:author | pubmed-author:CraftTT | lld:pubmed |
| pubmed-article:8454641 | pubmed:author | pubmed-author:CrisciAA | lld:pubmed |
| pubmed-article:8454641 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8454641 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:8454641 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:8454641 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8454641 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8454641 | pubmed:pagination | 6689-93 | lld:pubmed |
| pubmed-article:8454641 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:meshHeading | pubmed-meshheading:8454641-... | lld:pubmed |
| pubmed-article:8454641 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8454641 | pubmed:articleTitle | Construction of synthetic signals for glycosyl-phosphatidylinositol anchor attachment. Analysis of amino acid sequence requirements for anchoring. | lld:pubmed |
| pubmed-article:8454641 | pubmed:affiliation | Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110. | lld:pubmed |
| pubmed-article:8454641 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8454641 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8454641 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8454641 | lld:pubmed |
