Linked Life Data

8454049

Source:http://linkedlifedata.com/resource/pubmed/id/8454049

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pubmed-article:8454049pubmed:abstractTextThe imidazole antimycotics, miconazole, econazole and triclomazole as well as alpha-naphtoflavone, known as powerful inhibitors of cytochrome P450 and previously recognized as K+ channel blockers are shown to be potent activators of the base exchange enzyme system responsible for the biosynthesis of phosphatidylserine in Jurkat T cells. The inhibition of CD3-induced Ca2+ influx by antimycotics but not by K+ channel blockers, demonstrated that the rise in phosphatidylserine synthesis caused by the two classes of drugs, was independent of Ca2+ influx in the cells. In addition, we show that the action of these drugs on phosphatidylserine synthesis was not mimicked by modifications of membrane potential. The regulation of both K+ channels and the base exchange enzyme system thus occurs through a similar (or common) pathway that is independent of Ca(2+)-influx and membrane potential.lld:pubmed
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pubmed-article:8454049pubmed:articleTitleImidazole antimycotics inhibitors of cytochrome P450 increase phosphatidylserine synthesis similarly to K(+)-channel blockers in Jurkat T cells.lld:pubmed
pubmed-article:8454049pubmed:affiliationINSERM U343, Interactions cellulaires en Immunologie, Faculté de Médecine, Nice, France.lld:pubmed
pubmed-article:8454049pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8454049pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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