pubmed-article:8450829 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0034838 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:8450829 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:8450829 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:8450829 | pubmed:dateCreated | 1993-4-13 | lld:pubmed |
pubmed-article:8450829 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8450829 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8450829 | pubmed:abstractText | Serotonin [5-hydroxytryptamine (5-HT)] is a neuromodulator that mediates a wide range of physiological functions by activating multiple receptors. Using a strategy based on amino acid sequence homology between 5-HT receptors that interact with guanine nucleotide-binding proteins, we have isolated from a mouse brain library a cDNA encoding a new serotonin receptor. Amino acid sequence comparisons revealed that this receptor was a close relative of the previously identified 5-HT5 receptor but was distant from all other 5-HT receptor subtypes; we therefore named it 5-HT5B. When expressed in COS-7 cells, the 5-HT5B receptor displayed a high affinity for the serotonergic radioligand 125I-lysergic acid diethylamide. Its pharmacological profile was distinct from that of all classic 5-HT receptor subtypes. However, the high affinity of the 5-HT5B receptor for 5-carboxamidotryptamine and its low affinity for sumatriptan indicated that it might correspond to recently described 5-HT1D-like binding sites that were labeled with [3H]5-carboxamidotryptamine and insensitive to sumatriptan. In situ hybridization experiments revealed that the 5-HT5B mRNA was expressed predominantly in the habenula and in the CA1 field of the hippocampus. We also determined the chromosomal localization of the 5-HT5A and 5-HT5B genes and of their human counterparts. The 5-HT5A gene colocalized with the mouse mutation reeler and the human mutation holoprosencephaly type 3, which both result in abnormal brain development, raising the possibility that the 5-HT5A receptor plays a role in brain development. | lld:pubmed |
pubmed-article:8450829 | pubmed:language | eng | lld:pubmed |
pubmed-article:8450829 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8450829 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:8450829 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8450829 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8450829 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8450829 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8450829 | pubmed:month | Mar | lld:pubmed |
pubmed-article:8450829 | pubmed:issn | 0026-895X | lld:pubmed |
pubmed-article:8450829 | pubmed:author | pubmed-author:HenRR | lld:pubmed |
pubmed-article:8450829 | pubmed:author | pubmed-author:MatthesHH | lld:pubmed |
pubmed-article:8450829 | pubmed:author | pubmed-author:MatteiM GMG | lld:pubmed |
pubmed-article:8450829 | pubmed:author | pubmed-author:MuscatelliFF | lld:pubmed |
pubmed-article:8450829 | pubmed:author | pubmed-author:PlassatJ LJL | lld:pubmed |
pubmed-article:8450829 | pubmed:author | pubmed-author:AmlaikyNN | lld:pubmed |
pubmed-article:8450829 | pubmed:author | pubmed-author:BoschertUU | lld:pubmed |
pubmed-article:8450829 | pubmed:author | pubmed-author:GrailheRR | lld:pubmed |
pubmed-article:8450829 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8450829 | pubmed:volume | 43 | lld:pubmed |
pubmed-article:8450829 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8450829 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8450829 | pubmed:pagination | 313-9 | lld:pubmed |
pubmed-article:8450829 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:meshHeading | pubmed-meshheading:8450829-... | lld:pubmed |
pubmed-article:8450829 | pubmed:year | 1993 | lld:pubmed |
pubmed-article:8450829 | pubmed:articleTitle | Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. | lld:pubmed |
pubmed-article:8450829 | pubmed:affiliation | Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U/184 de l'INSERM, Département de Neurobiologie, Faculté de Médecine, Strasbourg, France. | lld:pubmed |
pubmed-article:8450829 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8450829 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:8450829 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:15563 | entrezgene:pubmed | pubmed-article:8450829 | lld:entrezgene |
entrez-gene:15564 | entrezgene:pubmed | pubmed-article:8450829 | lld:entrezgene |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8450829 | lld:pubmed |