| pubmed-article:8446255 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C0042036 | lld:lifeskim |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C2004491 | lld:lifeskim |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C0027697 | lld:lifeskim |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C0542560 | lld:lifeskim |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:8446255 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:8446255 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8446255 | pubmed:dateCreated | 1993-4-8 | lld:pubmed |
| pubmed-article:8446255 | pubmed:abstractText | Crescentic nephritis was induced in rabbits by injection of antirabbit glomerular basement membrane (GBM) antibodies. Urine samples were obtained by catheterization and assayed for transforming growth factor-beta (TGF-beta) activity. On day 31, all animals were sacrificed for evaluation of renal cortical histopathology and collagen content. The results show that control rabbit urine contains measurable amounts of TGF-beta. Urine TGF-beta activity was expressed in relation to urine creatinine concentration to correct for variation in urine concentration. When expressed in this manner, urine TGF-beta activity increased from day 2 onwards, peaked on day 7 and returned to normal levels after day 14. This time course is identical to that previously seen for the cortical and glomerular production of TGF-beta in the same model. Furthermore, when the normalized TGF-beta values for each animal were compared to their respective fibrosis parameters on day 31, significant correlations were observed for the values of urine TGF-beta activities on day 7 and all indices of fibrosis. These results suggest that measurements of urine TGF-beta activity at certain critical stages of disease could be useful in predicting the progression to end-stage renal disease with fibrosis and might serve as a helpful noninvasive adjunct in monitoring response to therapy. | lld:pubmed |
| pubmed-article:8446255 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8446255 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8446255 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8446255 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8446255 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8446255 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8446255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8446255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8446255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8446255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8446255 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8446255 | pubmed:issn | 0028-2766 | lld:pubmed |
| pubmed-article:8446255 | pubmed:author | pubmed-author:PhanS HSH | lld:pubmed |
| pubmed-article:8446255 | pubmed:author | pubmed-author:WigginsRR | lld:pubmed |
| pubmed-article:8446255 | pubmed:author | pubmed-author:HUGP LPL | lld:pubmed |
| pubmed-article:8446255 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8446255 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:8446255 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8446255 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8446255 | pubmed:pagination | 73-8 | lld:pubmed |
| pubmed-article:8446255 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:meshHeading | pubmed-meshheading:8446255-... | lld:pubmed |
| pubmed-article:8446255 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8446255 | pubmed:articleTitle | Urine transforming growth factor-beta activity is related to the degree of scarring in crescentic nephritis in the rabbit. | lld:pubmed |
| pubmed-article:8446255 | pubmed:affiliation | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0602. | lld:pubmed |
| pubmed-article:8446255 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8446255 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8446255 | lld:pubmed |
