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pubmed-article:8445423pubmed:abstractTextConsiderable attention has been focused on the chemopreventive properties of fenretinide against carcinogen-induced rodent mammary cancer. Less is known about its direct antitumor effects. The combination of tamoxifen and fenretinide is more effective than tamoxifen or fenretinide alone in prevention of rat mammary cancer. However, the combined toxicity of tamoxifen plus fenretinide in humans is unknown. Therefore, we performed a phase I/II trial in women with estrogen receptor (ER)-positive or progesterone receptor (PR)-positive, previously untreated metastatic breast cancer.lld:pubmed
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pubmed-article:8445423pubmed:articleTitlePhase I/II trial of tamoxifen with or without fenretinide, an analog of vitamin A, in women with metastatic breast cancer.lld:pubmed
pubmed-article:8445423pubmed:affiliationRush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612.lld:pubmed
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