| pubmed-article:8443394 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8443394 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:8443394 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8443394 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:8443394 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:8443394 | lifeskim:mentions | umls-concept:C0063710 | lld:lifeskim |
| pubmed-article:8443394 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8443394 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:8443394 | lifeskim:mentions | umls-concept:C1155002 | lld:lifeskim |
| pubmed-article:8443394 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8443394 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8443394 | pubmed:dateCreated | 1993-4-6 | lld:pubmed |
| pubmed-article:8443394 | pubmed:abstractText | Interleukin-1 (IL-1) profoundly affects a number of functions of endothelial cells (EC). It was previously shown that EC express the type I 80-Kd IL-1 receptor (IL-1 RI). In this study we define the expression and functional significance of the type II IL-1R (IL-1 RII) in EC. Human umbilical vein EC did not express appreciable levels of IL-1 RII mRNA as assessed by Northern analysis or reverse transcription and polymerase chain reaction. Exposure to various cytokines (including IL-4, which augments IL-1 RII in neutrophils) failed to induce IL-1 RII mRNA. The binding of radiolabeled IL-1 beta to EC was blocked by antitype I (M4) but not by antitype II (M22) monoclonal antibodies (MoAbs). MoAbs directed against the IL-1 RI (M1 and M4) inhibited the induction of IL-6 and adhesion molecules in EC by IL-1, whereas an anti-IL-1 RII (M22) was inactive. The human IL-1 receptor antagonist (IL-1ra) preferentially interacts with IL-1 RI versus IL-1 RII in the mouse. IL-1 ra inhibited the response of mouse endothelial cells to IL-1. We conclude that EC selectively express the IL-1 RI and that this is involved in the response of this cell type to IL-1. | lld:pubmed |
| pubmed-article:8443394 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8443394 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8443394 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8443394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8443394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8443394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8443394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8443394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8443394 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8443394 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8443394 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:8443394 | pubmed:author | pubmed-author:BernasconiSS | lld:pubmed |
| pubmed-article:8443394 | pubmed:author | pubmed-author:MantovaniAA | lld:pubmed |
| pubmed-article:8443394 | pubmed:author | pubmed-author:BoraschiDD | lld:pubmed |
| pubmed-article:8443394 | pubmed:author | pubmed-author:SironiMM | lld:pubmed |
| pubmed-article:8443394 | pubmed:author | pubmed-author:PollicinaFF | lld:pubmed |
| pubmed-article:8443394 | pubmed:author | pubmed-author:ColottaFF | lld:pubmed |
| pubmed-article:8443394 | pubmed:author | pubmed-author:BorrèAA | lld:pubmed |
| pubmed-article:8443394 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8443394 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8443394 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:8443394 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8443394 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8443394 | pubmed:pagination | 1347-51 | lld:pubmed |
| pubmed-article:8443394 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:meshHeading | pubmed-meshheading:8443394-... | lld:pubmed |
| pubmed-article:8443394 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8443394 | pubmed:articleTitle | Type II interleukin-1 receptor is not expressed in cultured endothelial cells and is not involved in endothelial cell activation. | lld:pubmed |
| pubmed-article:8443394 | pubmed:affiliation | Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy. | lld:pubmed |
| pubmed-article:8443394 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8443394 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8443394 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8443394 | lld:pubmed |
