| pubmed-article:8432962 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8432962 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8432962 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:8432962 | lifeskim:mentions | umls-concept:C0006023 | lld:lifeskim |
| pubmed-article:8432962 | lifeskim:mentions | umls-concept:C0525045 | lld:lifeskim |
| pubmed-article:8432962 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:8432962 | lifeskim:mentions | umls-concept:C0449851 | lld:lifeskim |
| pubmed-article:8432962 | lifeskim:mentions | umls-concept:C0949466 | lld:lifeskim |
| pubmed-article:8432962 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8432962 | pubmed:dateCreated | 1993-3-15 | lld:pubmed |
| pubmed-article:8432962 | pubmed:abstractText | Borna disease (BD) virus is a partially characterized neurotropic agent with a predilection for neurons and astrocytes in the limbic system and cerebrum of infected hosts. Although it usually causes a fatal encephalitis, some laboratory animals which have been experimentally inoculated can develop a persistent non-fatal infection characterized by a neuro-behavioral syndrome akin to human manic-depression. Using immunofluorescent techniques, we previously observed BD virus-specific antibodies in the sera of 4.5% of affectively ill patients, with the highest titers present in bipolar patients. More recently, we have developed a sensitive Western blot assay for the detection of anti-BD virus antibodies to a 38/40 kDa and 24 kDa protein in human serum. In the present study, we screened 138 affectively ill patients and 117 healthy controls and observed a significantly great proportion of patients with antibodies to the 38/40 kDa protein (P < 0.0001), the 24 kDa protein (P < 0.05) and both the 38/40 kDa and 24 kDa proteins (P < 0.025). These data extend prior reports on the presence of BD virus-specific antibodies in psychiatric patients, and suggest that a BD virus-like agent may be associated with affective illness in humans. | lld:pubmed |
| pubmed-article:8432962 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8432962 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8432962 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8432962 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8432962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8432962 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8432962 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8432962 | pubmed:issn | 0165-0327 | lld:pubmed |
| pubmed-article:8432962 | pubmed:author | pubmed-author:DietzscholdBB | lld:pubmed |
| pubmed-article:8432962 | pubmed:author | pubmed-author:KoprowskiHH | lld:pubmed |
| pubmed-article:8432962 | pubmed:author | pubmed-author:AmsterdamJ... | lld:pubmed |
| pubmed-article:8432962 | pubmed:author | pubmed-author:KarHH | lld:pubmed |
| pubmed-article:8432962 | pubmed:author | pubmed-author:ShankarVV | lld:pubmed |
| pubmed-article:8432962 | pubmed:author | pubmed-author:FuZ FZF | lld:pubmed |
| pubmed-article:8432962 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8432962 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:8432962 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8432962 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8432962 | pubmed:pagination | 61-8 | lld:pubmed |
| pubmed-article:8432962 | pubmed:dateRevised | 2009-9-28 | lld:pubmed |
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| pubmed-article:8432962 | pubmed:meshHeading | pubmed-meshheading:8432962-... | lld:pubmed |
| pubmed-article:8432962 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8432962 | pubmed:articleTitle | Detection of Borna disease virus-reactive antibodies from patients with affective disorders by western immunoblot technique. | lld:pubmed |
| pubmed-article:8432962 | pubmed:affiliation | Wistar Institute of Anatomy, Philadelphia, Pennsylvania. | lld:pubmed |
| pubmed-article:8432962 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8432962 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8432962 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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