| pubmed-article:8428961 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8428961 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8428961 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:8428961 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8428961 | lifeskim:mentions | umls-concept:C0031667 | lld:lifeskim |
| pubmed-article:8428961 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:8428961 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:8428961 | lifeskim:mentions | umls-concept:C1157324 | lld:lifeskim |
| pubmed-article:8428961 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8428961 | pubmed:dateCreated | 1993-3-8 | lld:pubmed |
| pubmed-article:8428961 | pubmed:abstractText | Previously, we have reported a novel proliferative action of pancreatic group I phospholipase A2 (PLA2-I) via a specific binding site in Swiss 3T3 fibroblasts, vascular smooth muscle cells, and chondrocytes. In this study, we characterized the PLA2-I specific binding site in osteoblastic cell line (MC3T3-E1 cells) with an equilibrium binding constant (Kd) value of 1.13 nM and maximum binding capacity of 40.1 fmol/10(6) cells. PLA2-I stimulated prostaglandin E2 (PGE2) production in a concentration-dependent manner in MC3T3-E1 cells, and its EC50 value was similar to the Kd value for PLA2-I binding. This effect of PLA2-I was type-specific and did not depend on its hydrolytic activity. PLA2-I increased the activity of prostaglandin endoperoxide synthase (PES), and PLA2-I-stimulated PGE2 synthesis was inhibited by cycloheximide. Northern blot analysis showed the increase in both type-1 and type-2 PES mRNAs. These findings indicated that PLA2-I stimulated PGE2 synthesis by induction of PES via a specific binding site in osteoblastic cells. | lld:pubmed |
| pubmed-article:8428961 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8428961 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8428961 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8428961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8428961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8428961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8428961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8428961 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8428961 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8428961 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8428961 | pubmed:author | pubmed-author:AritaHH | lld:pubmed |
| pubmed-article:8428961 | pubmed:author | pubmed-author:TohkinMM | lld:pubmed |
| pubmed-article:8428961 | pubmed:author | pubmed-author:IshizakiJJ | lld:pubmed |
| pubmed-article:8428961 | pubmed:author | pubmed-author:KishinoJJ | lld:pubmed |
| pubmed-article:8428961 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8428961 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:8428961 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:8428961 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8428961 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8428961 | pubmed:pagination | 2865-71 | lld:pubmed |
| pubmed-article:8428961 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8428961 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8428961 | pubmed:articleTitle | Pancreatic-type phospholipase A2 stimulates prostaglandin synthesis in mouse osteoblastic cells (MC3T3-E1) via a specific binding site. | lld:pubmed |
| pubmed-article:8428961 | pubmed:affiliation | Shionogi Research Laboratories, Shionogi and Co., Ltd., Osaka, Japan. | lld:pubmed |
| pubmed-article:8428961 | pubmed:publicationType | Journal Article | lld:pubmed |
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