| pubmed-article:8425221 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8425221 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8425221 | lifeskim:mentions | umls-concept:C1332794 | lld:lifeskim |
| pubmed-article:8425221 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:8425221 | lifeskim:mentions | umls-concept:C0221026 | lld:lifeskim |
| pubmed-article:8425221 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:8425221 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8425221 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8425221 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8425221 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8425221 | pubmed:dateCreated | 1993-3-2 | lld:pubmed |
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| pubmed-article:8425221 | pubmed:abstractText | We describe a novel cytoplasmic tyrosine kinase, termed BPK (B cell progenitor kinase), which is expressed in all stages of the B lineage and in myeloid cells. BPK has classic SH1, SH2, and SH3 domains, but lacks myristylation signals and a regulatory phosphorylation site corresponding to tyrosine 527 of c-src. BPK has a long, basic amino-terminal region upstream of the SH3 domain. BPK was evaluated as a candidate for human X-linked agammaglobulinemia (XLA), an inherited immunodeficiency characterized by a severe deficit of B and plasma cells and profound hypogammaglobulinemia. BPK mapped to within 100 kb of a probe defining the polymorphism most closely linked to XLA at DXS178. Reduction in or the absence of BPK mRNA, protein expression, and kinase activity was observed in XLA pre-B and B cell lines. BPK is likely the XLA gene and functions in pathways critical to B cell expansion. | lld:pubmed |
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| pubmed-article:8425221 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8425221 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8425221 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8425221 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8425221 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8425221 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:8425221 | pubmed:author | pubmed-author:AllenR CRC | lld:pubmed |
| pubmed-article:8425221 | pubmed:author | pubmed-author:SparkesR SRS | lld:pubmed |
| pubmed-article:8425221 | pubmed:author | pubmed-author:KubagawaHH | lld:pubmed |
| pubmed-article:8425221 | pubmed:author | pubmed-author:MohandasTT | lld:pubmed |
| pubmed-article:8425221 | pubmed:author | pubmed-author:KlisakII | lld:pubmed |
| pubmed-article:8425221 | pubmed:author | pubmed-author:TsukadaSS | lld:pubmed |
| pubmed-article:8425221 | pubmed:author | pubmed-author:QuanSS | lld:pubmed |
| pubmed-article:8425221 | pubmed:author | pubmed-author:ParoliniOO | lld:pubmed |
| pubmed-article:8425221 | pubmed:author | pubmed-author:RawlingsD JDJ | lld:pubmed |
| pubmed-article:8425221 | pubmed:author | pubmed-author:SaffranD CDC | lld:pubmed |
| pubmed-article:8425221 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8425221 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:8425221 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:8425221 | pubmed:geneSymbol | BPK | lld:pubmed |
| pubmed-article:8425221 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8425221 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:8425221 | pubmed:pagination | 279-90 | lld:pubmed |
| pubmed-article:8425221 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8425221 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8425221 | pubmed:articleTitle | Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. | lld:pubmed |
| pubmed-article:8425221 | pubmed:affiliation | Howard Hughes Medical Institute, University of California, Los Angeles 90024. | lld:pubmed |
| pubmed-article:8425221 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8425221 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8425221 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8425221 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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