| pubmed-article:8421704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8421704 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8421704 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:8421704 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:8421704 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8421704 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8421704 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:8421704 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8421704 | pubmed:dateCreated | 1993-2-18 | lld:pubmed |
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| pubmed-article:8421704 | pubmed:abstractText | Protein-tyrosine kinases have been implicated in signal transduction in T lymphocytes after stimulation of many cell-surface molecules, including the T-cell antigen receptor, CD4, CD8, CD2, CD5, and CD28. Yet the identities of many of these tyrosine kinases remain unknown. We have isolated a murine tyrosine kinase gene, called Tsk for T-cell-specific kinase, that appears to be exclusively expressed in T lymphocytes. The Tsk cDNA clone encodes a polypeptide of 70 kDa, which is similar in sequence to both the src and abl families of tyrosine kinases. Sequence comparisons also indicate that Tsk contains one src-homology region 2 domain and one src-homology 3 domain but lacks the negative regulatory tyrosine (src Tyr-527) common to src-family kinases. In addition, Tsk expression is developmentally regulated. Steady-state Tsk mRNA levels are 5- to 10-fold higher in thymocytes than in peripheral T cells and increase in the thymus during mouse development from neonate to adult. Furthermore, Tsk is expressed in day 14 fetal thymus, suggesting a role for Tsk in early T-lymphocyte differentiation. | lld:pubmed |
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| pubmed-article:8421704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8421704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8421704 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8421704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8421704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8421704 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8421704 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8421704 | pubmed:author | pubmed-author:BergL JLJ | lld:pubmed |
| pubmed-article:8421704 | pubmed:author | pubmed-author:HeyeckS DSD | lld:pubmed |
| pubmed-article:8421704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8421704 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8421704 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8421704 | pubmed:geneSymbol | Tsk | lld:pubmed |
| pubmed-article:8421704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8421704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8421704 | pubmed:pagination | 669-73 | lld:pubmed |
| pubmed-article:8421704 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8421704 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8421704 | pubmed:articleTitle | Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk. | lld:pubmed |
| pubmed-article:8421704 | pubmed:affiliation | Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138. | lld:pubmed |
| pubmed-article:8421704 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8421704 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8421704 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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