| pubmed-article:8421680 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8421680 | lifeskim:mentions | umls-concept:C0205094 | lld:lifeskim |
| pubmed-article:8421680 | lifeskim:mentions | umls-concept:C0012120 | lld:lifeskim |
| pubmed-article:8421680 | lifeskim:mentions | umls-concept:C0392752 | lld:lifeskim |
| pubmed-article:8421680 | lifeskim:mentions | umls-concept:C0324024 | lld:lifeskim |
| pubmed-article:8421680 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8421680 | pubmed:dateCreated | 1993-2-18 | lld:pubmed |
| pubmed-article:8421680 | pubmed:abstractText | Differentiation-inducing factor 1 [DIF-1; 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)-hexan-1-one] induces stalk cell differentiation during Dictyostelium development. It is present as a gradient in the multicellular slug, its lowest concentration being in the anterior. Here we demonstrate the existence of a localized sink for DIF-1, also in the anterior of the slug, which could be responsible for generating the DIF-1 gradient. DIF-1 is metabolized extensively by developing cells, initially by a mono-dechlorination. We used an enzyme assay for DIF-1 dechlorinase to examine its distribution in the slug. DIF-1 dechlorinase activity is 30-fold higher in prestalk cells (largely anterior) compared with prespore cells (posterior) when these are separated from each other on Percoll density gradients. Dissection experiments showed that DIF-1 dechlorinase is 25-fold enriched in the anterior 13% of the slug compared with the rest. These experiments also showed that DIF-1 dechlorinase is more anterior-enriched than the standard prestalk markers, the ecmA and ecmB mRNAs. When cut from a slug, both prestalk and prespore fragments regulate to restore the missing cell type. Prespore fragments rapidly regain (by 30 min) a DIF-1 sink in their anteriors, and prestalk fragments restore a posterior zone with low DIF-1 dechlorinase by 4 hr after cutting. The reappearance of the DIF-1 sink in the anterior of prespore fragments is accomplished without detectable cell sorting and may, therefore, be in response to positional signals. Finally, a localized sink may provide a general way of producing a gradient of a signal substance in a developing embryo. | lld:pubmed |
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| pubmed-article:8421680 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8421680 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8421680 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8421680 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8421680 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8421680 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8421680 | pubmed:author | pubmed-author:LINS CSC | lld:pubmed |
| pubmed-article:8421680 | pubmed:author | pubmed-author:LargeSS | lld:pubmed |
| pubmed-article:8421680 | pubmed:author | pubmed-author:NaylerOO | lld:pubmed |
| pubmed-article:8421680 | pubmed:author | pubmed-author:TraynorDD | lld:pubmed |
| pubmed-article:8421680 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8421680 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8421680 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8421680 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8421680 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8421680 | pubmed:pagination | 487-91 | lld:pubmed |
| pubmed-article:8421680 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8421680 | pubmed:meshHeading | pubmed-meshheading:8421680-... | lld:pubmed |
| pubmed-article:8421680 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8421680 | pubmed:articleTitle | A localized differentiation-inducing-factor sink in the front of the Dictyostelium slug. | lld:pubmed |
| pubmed-article:8421680 | pubmed:affiliation | Medical Research Council Laboratory of Molecular Biology, Cambridge, England. | lld:pubmed |
| pubmed-article:8421680 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8421680 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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