| pubmed-article:8421076 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8421076 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:8421076 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8421076 | lifeskim:mentions | umls-concept:C0549473 | lld:lifeskim |
| pubmed-article:8421076 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:8421076 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:8421076 | lifeskim:mentions | umls-concept:C0596138 | lld:lifeskim |
| pubmed-article:8421076 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:8421076 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:8421076 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8421076 | pubmed:dateCreated | 1993-2-17 | lld:pubmed |
| pubmed-article:8421076 | pubmed:abstractText | We reported first in this study that human thyroid cell line NIM 1 established from a patient with papillary adenocarcinoma of the thyroid associated with hypercalcemia and peripheral neutrocytosis produced interleukin (IL)-1 alpha and IL-1 beta in the culture supernatant and cell lysate as detected by murine thymocyte proliferative response and enzyme-linked immunosorbent assay. Production of IL-1 alpha and IL-1 beta was further confirmed by the demonstration of IL-1 alpha and IL-1 beta messenger ribonucleic acid expression with Northern blot hybridization analysis. The in vitro growth of NIM 1 cells was inhibited by the addition of anti-IL-1 alpha and IL-1 beta antibody. The growth of NIM 1 cells was further enhanced by the addition of recombinant human IL-1 alpha and IL-1 beta, whereas this enhancement was also inhibited by the addition of anti-IL-1 antibody. IL-1 receptors were expressed on NIM 1 cells. These results suggest that IL-1 plays a regulatory role in the growth of NIM 1 cells by an autocrine mechanism. | lld:pubmed |
| pubmed-article:8421076 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8421076 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8421076 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8421076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8421076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8421076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8421076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8421076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8421076 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8421076 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8421076 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:8421076 | pubmed:author | pubmed-author:WatanabeKK | lld:pubmed |
| pubmed-article:8421076 | pubmed:author | pubmed-author:NakanoYY | lld:pubmed |
| pubmed-article:8421076 | pubmed:author | pubmed-author:EtoSS | lld:pubmed |
| pubmed-article:8421076 | pubmed:author | pubmed-author:YamashitaUU | lld:pubmed |
| pubmed-article:8421076 | pubmed:author | pubmed-author:MorimotoII | lld:pubmed |
| pubmed-article:8421076 | pubmed:author | pubmed-author:ZekiKK | lld:pubmed |
| pubmed-article:8421076 | pubmed:author | pubmed-author:InokuchiNN | lld:pubmed |
| pubmed-article:8421076 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8421076 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:8421076 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8421076 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8421076 | pubmed:pagination | 127-33 | lld:pubmed |
| pubmed-article:8421076 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8421076 | pubmed:meshHeading | pubmed-meshheading:8421076-... | lld:pubmed |
| pubmed-article:8421076 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8421076 | pubmed:articleTitle | Autocrine stimulation of interleukin-1 in the growth of human thyroid carcinoma cell line NIM 1. | lld:pubmed |
| pubmed-article:8421076 | pubmed:affiliation | First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. | lld:pubmed |
| pubmed-article:8421076 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8421076 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8421076 | lld:pubmed |
