| pubmed-article:8419493 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8419493 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:8419493 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8419493 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8419493 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:8419493 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:8419493 | lifeskim:mentions | umls-concept:C1423585 | lld:lifeskim |
| pubmed-article:8419493 | lifeskim:mentions | umls-concept:C1819882 | lld:lifeskim |
| pubmed-article:8419493 | lifeskim:mentions | umls-concept:C0059386 | lld:lifeskim |
| pubmed-article:8419493 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8419493 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8419493 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8419493 | pubmed:dateCreated | 1993-2-5 | lld:pubmed |
| pubmed-article:8419493 | pubmed:abstractText | This study examines the responses of lupus-prone NZB, (NZB x NZW) F1, BXSB, MRL-lpr/lpr and control mice (H-2 and Mls matched) to in vivo administration of the superantigen staphylococcal enterotoxin B (SEB). Two weeks after i.v. administration of 500 micrograms SEB, CD4+V beta 8+ lymph node T cells were deleted equivalently by lupus-prone and control mice. However, IE+ strains deleted a greater proportion (47% to 77%) of their CD4+V beta 8+ cells than did IE- strains (24% to 27%). CD8+V beta 8+ cells were deleted less than CD4+V beta 8+ cells by injection of 500 micrograms SEB. IE- strains failed to delete CD8+V beta 8+ cells, whereas six of seven IE+ strains deleted > 25% of their CD8+V beta 8+ cells. IE+ MRL-lpr/lpr mice showed some impairment in deletion: they failed to delete CD8+V beta 8+ cells at all doses of SEB and had reduced deletion of CD4+V beta 8+ cells at low doses of in vivo SEB (10 and 50 micrograms). Peripheral expansion of the intrathymically deleted V beta 7 TCR family was not observed in lupus-prone mice 2 wk after 500 micrograms in vivo SEB. In vitro restimulation with SEB of mice previously injected with 500 micrograms SEB demonstrated anergy in T cells from all strains, including the IE- and MRL-lpr/lpr. This result contrasts with previous reports of tolerance defects in lupus-prone strains using B cell read-out assays as measures of tolerance. The present study demonstrates that there is no global defect in peripheral T cell deletion or anergy in lupus-prone mice to the superantigen SEB. Although additional Ag would need to be studied, these experiments raise the possibility that some reported tolerance defects in lupus-prone strains may reflect excessive B cell responses to relatively normal T cell signals. | lld:pubmed |
| pubmed-article:8419493 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8419493 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8419493 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8419493 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8419493 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8419493 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8419493 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8419493 | pubmed:author | pubmed-author:SteinbergA... | lld:pubmed |
| pubmed-article:8419493 | pubmed:author | pubmed-author:ScottD EDE | lld:pubmed |
| pubmed-article:8419493 | pubmed:author | pubmed-author:KischW JWJ | lld:pubmed |
| pubmed-article:8419493 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8419493 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8419493 | pubmed:volume | 150 | lld:pubmed |
| pubmed-article:8419493 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8419493 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8419493 | pubmed:pagination | 664-72 | lld:pubmed |
| pubmed-article:8419493 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8419493 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8419493 | pubmed:articleTitle | Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice. | lld:pubmed |
| pubmed-article:8419493 | pubmed:affiliation | Cellular Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:8419493 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8419493 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14102 | entrezgene:pubmed | pubmed-article:8419493 | lld:entrezgene |
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