| pubmed-article:8418054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8418054 | lifeskim:mentions | umls-concept:C0043408 | lld:lifeskim |
| pubmed-article:8418054 | lifeskim:mentions | umls-concept:C0302583 | lld:lifeskim |
| pubmed-article:8418054 | lifeskim:mentions | umls-concept:C0018988 | lld:lifeskim |
| pubmed-article:8418054 | lifeskim:mentions | umls-concept:C1881215 | lld:lifeskim |
| pubmed-article:8418054 | lifeskim:mentions | umls-concept:C1698986 | lld:lifeskim |
| pubmed-article:8418054 | lifeskim:mentions | umls-concept:C0182967 | lld:lifeskim |
| pubmed-article:8418054 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8418054 | pubmed:dateCreated | 1993-1-29 | lld:pubmed |
| pubmed-article:8418054 | pubmed:abstractText | It is established that a high-frequency chromosomal deletion of ca. 100 kb accounts for the loss of properties making up the pigmented phenotype (Pgm+) of wild-type Yersinia pestis. These determinants are known to include virulence by peripheral routes of injection, sensitivity to the bacteriocin pesticin, adsorption of exogenous hemin or Congo red at 26 degrees C, and growth in iron-sequestered medium at 37 degrees C. We have now identified the outer membrane as the primary site of exogenous hemin storage in Pgm+ cells grown at 26 degrees C. Significant outer membrane storage of hemin did not occur in Pgm- mutants or in Pgm+ cells cultivated at 37 degrees C. However, both Pgm+ and Pgm- organisms grown at 37 degrees C contained a periplasmic reservoir of hemin, which may be associated with a temperature-dependent ca. 70-kDa peptide recently equated with antigen 5. At 37 degrees C, Pgm+ and Pgm- yersiniae also utilized a cytoplasmic ca. 19-kDa bacterioferritin-like peptide for deposition of inorganic iron. Incorporation of [55Fe]hemin into pools at 37 degrees C was not significantly inhibited by competition with excess unlabeled Fe3+. However, excess unlabeled hemin modestly competed with incorporation of label from 55FeCl3. This relative independence of storage pools observed at 37 degrees C is consistent with physiological linkage to in vivo acquisition and transport of Fe3+ from ferritin and of hemin from hemoglobin, myoglobin, or hemopexin. | lld:pubmed |
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| pubmed-article:8418054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8418054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8418054 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8418054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8418054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8418054 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8418054 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:8418054 | pubmed:author | pubmed-author:BrubakerR RRR | lld:pubmed |
| pubmed-article:8418054 | pubmed:author | pubmed-author:PerryR DRD | lld:pubmed |
| pubmed-article:8418054 | pubmed:author | pubmed-author:SikkemaD JDJ | lld:pubmed |
| pubmed-article:8418054 | pubmed:author | pubmed-author:LucierT STS | lld:pubmed |
| pubmed-article:8418054 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8418054 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:8418054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8418054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8418054 | pubmed:pagination | 32-9 | lld:pubmed |
| pubmed-article:8418054 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8418054 | pubmed:meshHeading | pubmed-meshheading:8418054-... | lld:pubmed |
| pubmed-article:8418054 | pubmed:year | 1993 | lld:pubmed |
