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pubmed-article:8418010pubmed:abstractTextTwenty-two consecutive cases of adenoma in acromegalic patients were studied immunohistochemically. All the tumors contained prolactin (PRL)-reactive cells (3% to 53% of the total number of tumor cells) as well as growth hormone (GH)-reactive cells (4% to 74% of the total number of tumor cells). All acromegalic cases studied were thus plurihormonal adenomas containing GH and PRL; no pure GH cell adenoma was present. Twenty cases were further examined at the ultrastructural level in conjunction with postembedding double-labeling immunoelectron microscopy; 15 of these cases were diagnosed as mixed GH cell-PRL cell adenomas. The previously diagnosed pure GH cell adenomas possibly may have contained PRL cells and thus should be considered as mixed GH cell-PRL cell adenomas. Mammosomatotroph adenomas were rare in this series. Double-labeling immunoelectron microscopy, using protein A gold particles of two different sizes, greatly facilitated the distinction among GH, PRL, and mammosomatotroph cells.lld:pubmed
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pubmed-article:8418010pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8418010pubmed:year1993lld:pubmed
pubmed-article:8418010pubmed:articleTitleProlactin presents in all pituitary tumors of acromegalic patients.lld:pubmed
pubmed-article:8418010pubmed:affiliationDepartment of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.lld:pubmed
pubmed-article:8418010pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8418010pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed