| pubmed-article:8416881 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8416881 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8416881 | lifeskim:mentions | umls-concept:C0930553 | lld:lifeskim |
| pubmed-article:8416881 | lifeskim:mentions | umls-concept:C0043352 | lld:lifeskim |
| pubmed-article:8416881 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8416881 | lifeskim:mentions | umls-concept:C2826285 | lld:lifeskim |
| pubmed-article:8416881 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8416881 | pubmed:dateCreated | 1993-1-28 | lld:pubmed |
| pubmed-article:8416881 | pubmed:abstractText | Radiation therapy for cancer of the head and neck region often causes salivary gland dysfunction and xerostomia. Several reports suggest that the submandibular/sublingual (SM/SL) glands may be less radiosensitive than the parotid. The purpose of this study was to evaluate differential radiation effects on the major salivary glands. Fifty patients with radiation-induced xerostomia were evaluated (33 males, 17 females; mean age 52.7). The average total tumor dose was 6034 cGy. Major salivary gland function was compared with that of 50 non-irradiated controls. Salivary flow rates included unstimulated and stimulated flows of both the parotid and SM/SL glands. Sialochemical analyses included total protein, lysozyme, lactoferrin, sodium, chloride, and potassium. All four measures of salivary flow were significantly reduced in patients as compared to controls (p = .0001). Like the parotid, submandibular/sublingual gland dysfunction appears to be radiation dose- and field-dependent. Patients in the lowest radiation dose quartile (< or = 5000 cGy) had significantly increased salivary flow compared to those in the highest dose quartile (> or = 6800 cGy; p = .025). Glands that were partially irradiated were more likely to have some residual function than fully irradiated glands (p = .003). Lactoferrin content was increased in parotid saliva of radiation patients (p = .0001). Chloride content was significantly increased also (p = .0001). The SM/SL glands are clearly dysfunctional in post-irradiation xerostomia patients compared to controls, in terms of both flow rates and sialochemistry. | lld:pubmed |
| pubmed-article:8416881 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8416881 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8416881 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8416881 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8416881 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8416881 | pubmed:issn | 0360-3016 | lld:pubmed |
| pubmed-article:8416881 | pubmed:author | pubmed-author:FoxP CPC | lld:pubmed |
| pubmed-article:8416881 | pubmed:author | pubmed-author:AtkinsonJ CJC | lld:pubmed |
| pubmed-article:8416881 | pubmed:author | pubmed-author:ShipJ AJA | lld:pubmed |
| pubmed-article:8416881 | pubmed:author | pubmed-author:ValdezI HIH | lld:pubmed |
| pubmed-article:8416881 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8416881 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:8416881 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8416881 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8416881 | pubmed:pagination | 41-7 | lld:pubmed |
| pubmed-article:8416881 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:meshHeading | pubmed-meshheading:8416881-... | lld:pubmed |
| pubmed-article:8416881 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8416881 | pubmed:articleTitle | Major salivary gland function in patients with radiation-induced xerostomia: flow rates and sialochemistry. | lld:pubmed |
| pubmed-article:8416881 | pubmed:affiliation | Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:8416881 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8416881 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8416881 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8416881 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8416881 | lld:pubmed |
