| pubmed-article:8408661 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8408661 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8408661 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:8408661 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:8408661 | lifeskim:mentions | umls-concept:C0019134 | lld:lifeskim |
| pubmed-article:8408661 | lifeskim:mentions | umls-concept:C0079284 | lld:lifeskim |
| pubmed-article:8408661 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8408661 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8408661 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8408661 | pubmed:dateCreated | 1993-11-12 | lld:pubmed |
| pubmed-article:8408661 | pubmed:abstractText | Heparin shows blood pressure lowering effect in hypertensive patients and animal models. The present study examined the effect of heparin on vasoconstrictor endothelin-1 (ET-1) production in cultured human umbilical vein endothelial cells (ECs) to elucidate the mechanism of antihypertensive effect of heparin. Heparin suppressed both basal and thrombin-stimulated ET-1 mRNA expression paralleled with a decrease in ET-1 peptide release in a dose-dependent manner. Heparin concomitantly enhanced nitric oxide (NO) formation measured by NO2/NO3 levels and cGMP production in ECs. These enhancements were more marked when ECs were stimulated by thrombin. However, these heparin's effects were blunted in the presence of endothelium-derived nitric oxide (EDNO) synthesizing inhibitor NG-monomethyl L-arginine. Therefore, these results suggest that suppression of ET-1 production by heparin is EDNO mediated. | lld:pubmed |
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| pubmed-article:8408661 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8408661 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8408661 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8408661 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8408661 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:8408661 | pubmed:author | pubmed-author:KohnoMM | lld:pubmed |
| pubmed-article:8408661 | pubmed:author | pubmed-author:MandalA KAK | lld:pubmed |
| pubmed-article:8408661 | pubmed:author | pubmed-author:YanagisawaMM | lld:pubmed |
| pubmed-article:8408661 | pubmed:author | pubmed-author:TakedaTT | lld:pubmed |
| pubmed-article:8408661 | pubmed:author | pubmed-author:TaharaHH | lld:pubmed |
| pubmed-article:8408661 | pubmed:author | pubmed-author:YokokawaKK | lld:pubmed |
| pubmed-article:8408661 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8408661 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:8408661 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8408661 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8408661 | pubmed:pagination | 2080-5 | lld:pubmed |
| pubmed-article:8408661 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8408661 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8408661 | pubmed:articleTitle | Heparin regulates endothelin production through endothelium-derived nitric oxide in human endothelial cells. | lld:pubmed |
| pubmed-article:8408661 | pubmed:affiliation | First Department of Internal Medicine, Osaka City University Medical School, Japan. | lld:pubmed |
| pubmed-article:8408661 | pubmed:publicationType | Journal Article | lld:pubmed |
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