| pubmed-article:8408247 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8408247 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8408247 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:8408247 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:8408247 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:8408247 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8408247 | lifeskim:mentions | umls-concept:C0032200 | lld:lifeskim |
| pubmed-article:8408247 | lifeskim:mentions | umls-concept:C1515406 | lld:lifeskim |
| pubmed-article:8408247 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8408247 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8408247 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8408247 | pubmed:dateCreated | 1993-11-5 | lld:pubmed |
| pubmed-article:8408247 | pubmed:abstractText | We have previously found that transforming growth factor-beta 1 (TGF-beta 1) inhibits the mitogenic activity of platelet-derived growth factor (PDGF) in cultures of human neonatal fibroblasts in a density-dependent fashion. In the present investigation we determined the effect of TGF-beta 1 on the PDGF alpha-receptor, which binds all PDGF isoforms, as well as on the beta-receptor, which binds only PDGF-BB with high affinity. We found that the inhibitory effect of TGF-beta 1 on PDGF-AA-induced mitogenesis was density-dependent; when dense cell cultures were preincubated with TGF-beta 1, there was an complete inhibition of 3H-thymidine incorporation, whereas the effect was less in sparse cultures. A similar density-dependent effect of TGF-beta 1 was seen in PDGF-BB treated cells, although less pronounced. The binding of 125I-labeled PDGF-AA and PDGF-BB to the alpha-receptor was significantly reduced after treatment with TGF-beta 1 in dense cultures, whereas the sparse cultures were less affected. A decrease of alpha-receptor mRNA was also seen. The levels of beta-receptor protein and mRNA were unaffected. We conclude that the growth inhibitory effect of TGF-beta 1 is cell density-dependent and involves down-regulation of PDGF alpha-receptors. | lld:pubmed |
| pubmed-article:8408247 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8408247 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8408247 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8408247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8408247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8408247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8408247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8408247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8408247 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8408247 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8408247 | pubmed:issn | 0021-9541 | lld:pubmed |
| pubmed-article:8408247 | pubmed:author | pubmed-author:WestermarkBB | lld:pubmed |
| pubmed-article:8408247 | pubmed:author | pubmed-author:HeldinC HCH | lld:pubmed |
| pubmed-article:8408247 | pubmed:author | pubmed-author:KarlssonCC | lld:pubmed |
| pubmed-article:8408247 | pubmed:author | pubmed-author:PaulssonYY | lld:pubmed |
| pubmed-article:8408247 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8408247 | pubmed:volume | 157 | lld:pubmed |
| pubmed-article:8408247 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8408247 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8408247 | pubmed:pagination | 97-103 | lld:pubmed |
| pubmed-article:8408247 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:meshHeading | pubmed-meshheading:8408247-... | lld:pubmed |
| pubmed-article:8408247 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8408247 | pubmed:articleTitle | Density-dependent inhibitory effect of transforming growth factor-beta 1 on human fibroblasts involves the down-regulation of platelet-derived growth factor alpha-receptors. | lld:pubmed |
| pubmed-article:8408247 | pubmed:affiliation | Department of Pathology, University Hospital, Uppsala, Sweden. | lld:pubmed |
| pubmed-article:8408247 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8408247 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8408247 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8408247 | lld:pubmed |
