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| pubmed-article:8405712 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8405712 | pubmed:dateCreated | 1993-11-22 | lld:pubmed |
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| pubmed-article:8405712 | pubmed:abstractText | A complementary DNA for a glucagon-like peptide-1 receptor was isolated from a human pancreatic islet cDNA library. The isolated clone encoded a protein with 90% identity to the rat receptor. In stably transfected fibroblasts, the receptor bound [125I]GLP-1 with high affinity (Kd = 0.5 nM) and was coupled to adenylate cyclase as detected by a GLP-1-dependent increase in cAMP production (EC50 = 93 pM). Two peptides from the venom of the lizard Heloderma suspectum, exendin-4 and exendin-(9-39), displayed similar ligand binding affinities to the human GLP-1 receptor. Whereas exendin-4 acted as an agonist of the receptor, inducing cAMP formation, exendin-(9-39) was an antagonist of the receptor, inhibiting GLP-1-induced cAMP production. Because GLP-1 has been proposed as a potential agent for treatment of NIDDM, our present data will contribute to the characterization of the receptor binding site and the development of new agonists of this receptor. | lld:pubmed |
| pubmed-article:8405712 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8405712 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8405712 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8405712 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8405712 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:8405712 | pubmed:author | pubmed-author:MorelPP | lld:pubmed |
| pubmed-article:8405712 | pubmed:author | pubmed-author:ThorensBB | lld:pubmed |
| pubmed-article:8405712 | pubmed:author | pubmed-author:WidmannCC | lld:pubmed |
| pubmed-article:8405712 | pubmed:author | pubmed-author:DengS PSP | lld:pubmed |
| pubmed-article:8405712 | pubmed:author | pubmed-author:BühlerLL | lld:pubmed |
| pubmed-article:8405712 | pubmed:author | pubmed-author:PorretAA | lld:pubmed |
| pubmed-article:8405712 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8405712 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:8405712 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8405712 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8405712 | pubmed:pagination | 1678-82 | lld:pubmed |
| pubmed-article:8405712 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8405712 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8405712 | pubmed:articleTitle | Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. | lld:pubmed |
| pubmed-article:8405712 | pubmed:affiliation | Department of Pharmacology and Toxicology, University of Lausanne, Switzerland. | lld:pubmed |
| pubmed-article:8405712 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8405712 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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