| pubmed-article:8405113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8405113 | lifeskim:mentions | umls-concept:C0009170 | lld:lifeskim |
| pubmed-article:8405113 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:8405113 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:8405113 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:8405113 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:8405113 | lifeskim:mentions | umls-concept:C0205341 | lld:lifeskim |
| pubmed-article:8405113 | lifeskim:mentions | umls-concept:C1415803 | lld:lifeskim |
| pubmed-article:8405113 | lifeskim:mentions | umls-concept:C1152740 | lld:lifeskim |
| pubmed-article:8405113 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:8405113 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:8405113 | pubmed:dateCreated | 1993-11-9 | lld:pubmed |
| pubmed-article:8405113 | pubmed:abstractText | In order to examine whether cocaine-induced behavioral sensitization is modulated by changes in serotonin receptor subtypes, we measured the binding of [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) to 5-HT1A receptors and of [3H]-ketanserin to 5-HT2 receptors in various brain regions of cocaine-treated and saline-treated (control) rats. As previously reported, repeated administration of cocaine resulted in behavioral sensitization. Stereotypic scores with the cocaine challenge were significantly (P < 0.05) higher in cocaine-pretreated animals than in the saline-pretreated group. Neither acute nor chronic cocaine administration significantly altered the number (Bmax) or the affinity (KD) of either [3H]8-OH-DPAT or [3H]ketanserin binding sites in any of the brain regions examined. These results suggest that the enhanced functional sensitivity of 5-HT1A or 5-HT2 receptor subtypes seen with cocaine may be associated with alterations in processes distal to receptors rather than changes in the number or the affinity of the receptors. | lld:pubmed |
| pubmed-article:8405113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8405113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8405113 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8405113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8405113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8405113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8405113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8405113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8405113 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8405113 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:8405113 | pubmed:author | pubmed-author:DavisJ MJM | lld:pubmed |
| pubmed-article:8405113 | pubmed:author | pubmed-author:JavaidJ IJI | lld:pubmed |
| pubmed-article:8405113 | pubmed:author | pubmed-author:PandeyS CSC | lld:pubmed |
| pubmed-article:8405113 | pubmed:author | pubmed-author:SahniS KSK | lld:pubmed |
| pubmed-article:8405113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8405113 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:8405113 | pubmed:volume | 238 | lld:pubmed |
| pubmed-article:8405113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8405113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8405113 | pubmed:pagination | 425-9 | lld:pubmed |
| pubmed-article:8405113 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:meshHeading | pubmed-meshheading:8405113-... | lld:pubmed |
| pubmed-article:8405113 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8405113 | pubmed:articleTitle | Repeated cocaine administration does not affect 5-HT receptor subtypes (5-HT1A, 5-HT2) in several rat brain regions. | lld:pubmed |
| pubmed-article:8405113 | pubmed:affiliation | Illinois State Psychiatric Institute, Chicago 60651. | lld:pubmed |
| pubmed-article:8405113 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8405113 | pubmed:publicationType | Comparative Study | lld:pubmed |
