| pubmed-article:8397494 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8397494 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:8397494 | lifeskim:mentions | umls-concept:C0033860 | lld:lifeskim |
| pubmed-article:8397494 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
| pubmed-article:8397494 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:8397494 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:8397494 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8397494 | pubmed:dateCreated | 1993-10-20 | lld:pubmed |
| pubmed-article:8397494 | pubmed:abstractText | Lesional psoriatic skin displays reduced responsiveness to beta-adrenergic stimulating agents. To elucidate whether the receptor protein itself is responsible for this, lesional and non-lesional psoriatic skin was investigated ex vivo for maximal beta-adrenergic binding density (Bmax) and beta-adrenergic binding affinity (KD). Epidermal crude membrane homogenates (ECMH) were prepared from split-thickness skin biopsies and saturated with the lipophilic beta-adrenergic antagonist (-)-125I-iodocyanopindolol (ICYP) as radioligand. Specific binding was saturable and Scatchard transformation of the binding data revealed a homogeneous class of beta-adrenergic receptors in all nine experiments. The maximal beta-adrenergic binding density was significantly less in lesional than in non-lesional psoriatic skin (Bmax = 49.7 +/- 7.2 fmol/mg protein vs. 67.1 +/- 2.2 fmol/mg protein, n = 9, P < 0.05). The binding affinity was similar in lesional and in non-lesional skin (KD = 9.0 +/- 1.5 pmol/l vs. 8.0 +/- 0.9 pmol/l). These results could at least partially explain the reduced responsiveness of the beta-adrenergic system in lesional psoriatic skin seen after stimulation with beta-adrenergic agonists. | lld:pubmed |
| pubmed-article:8397494 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8397494 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8397494 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8397494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8397494 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8397494 | pubmed:issn | 0340-3696 | lld:pubmed |
| pubmed-article:8397494 | pubmed:author | pubmed-author:SteinfathMM | lld:pubmed |
| pubmed-article:8397494 | pubmed:author | pubmed-author:MensingHH | lld:pubmed |
| pubmed-article:8397494 | pubmed:author | pubmed-author:KörnerCC | lld:pubmed |
| pubmed-article:8397494 | pubmed:author | pubmed-author:SteinkrausVV | lld:pubmed |
| pubmed-article:8397494 | pubmed:author | pubmed-author:AbeckDD | lld:pubmed |
| pubmed-article:8397494 | pubmed:author | pubmed-author:StöveLL | lld:pubmed |
| pubmed-article:8397494 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8397494 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:8397494 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8397494 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8397494 | pubmed:pagination | 300-4 | lld:pubmed |
| pubmed-article:8397494 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:8397494 | pubmed:meshHeading | pubmed-meshheading:8397494-... | lld:pubmed |
| pubmed-article:8397494 | pubmed:meshHeading | pubmed-meshheading:8397494-... | lld:pubmed |
| pubmed-article:8397494 | pubmed:meshHeading | pubmed-meshheading:8397494-... | lld:pubmed |
| pubmed-article:8397494 | pubmed:meshHeading | pubmed-meshheading:8397494-... | lld:pubmed |
| pubmed-article:8397494 | pubmed:meshHeading | pubmed-meshheading:8397494-... | lld:pubmed |
| pubmed-article:8397494 | pubmed:meshHeading | pubmed-meshheading:8397494-... | lld:pubmed |
| pubmed-article:8397494 | pubmed:meshHeading | pubmed-meshheading:8397494-... | lld:pubmed |
| pubmed-article:8397494 | pubmed:meshHeading | pubmed-meshheading:8397494-... | lld:pubmed |
| pubmed-article:8397494 | pubmed:meshHeading | pubmed-meshheading:8397494-... | lld:pubmed |
| pubmed-article:8397494 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8397494 | pubmed:articleTitle | Beta-adrenergic receptors in psoriasis: evidence for down-regulation in lesional skin. | lld:pubmed |
| pubmed-article:8397494 | pubmed:affiliation | Department of Dermatology, University of Hamburg, Germany. | lld:pubmed |
| pubmed-article:8397494 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8397494 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8397494 | lld:pubmed |
