| pubmed-article:8394695 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8394695 | lifeskim:mentions | umls-concept:C0021547 | lld:lifeskim |
| pubmed-article:8394695 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:8394695 | lifeskim:mentions | umls-concept:C1515122 | lld:lifeskim |
| pubmed-article:8394695 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8394695 | lifeskim:mentions | umls-concept:C1149848 | lld:lifeskim |
| pubmed-article:8394695 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8394695 | pubmed:dateCreated | 1993-9-14 | lld:pubmed |
| pubmed-article:8394695 | pubmed:abstractText | Stimulation of the human T-cell line, Jurkat, by a monoclonal antibody (mAb) directed against the CD28 molecule leads to sustained increases in intracellular levels of Ca2+ ([Ca2+]i); the initial rise in Ca2+ comes from internal stores, followed by Ca2+ entry into the cells. The CD28 molecule also appears to activate polyphosphoinositide (InsPL)-specific phospholipase C (PLC) activity in Jurkat cells, as demonstrated by PtdInsP2 breakdown, InsP3 and 1,2-diacylglycerol generation and PtdIns resynthesis. We also observed that interleukin-2 (IL2) production induced via CD28 triggering was sensitive to a selective protein kinase C inhibitor. Of the four other anti-CD28 mAbs (CD28.2, CD28.4, CD28.5, CD28.6) tested, only one (CD28.5) was unable to generate any InsPL-specific PLC or IL2 secretion. However, the cross-linking of cell-bound CD28.5 with anti-mouse Ig antibodies led to an increase in [Ca2+]i. CD28-molecule clustering in itself appears to be a sufficient signal for induction of PLC activity. | lld:pubmed |
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| pubmed-article:8394695 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8394695 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8394695 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8394695 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8394695 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8394695 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:8394695 | pubmed:author | pubmed-author:NunezCC | lld:pubmed |
| pubmed-article:8394695 | pubmed:author | pubmed-author:OlivaHH | lld:pubmed |
| pubmed-article:8394695 | pubmed:author | pubmed-author:MawasCC | lld:pubmed |
| pubmed-article:8394695 | pubmed:author | pubmed-author:BagnascoMM | lld:pubmed |
| pubmed-article:8394695 | pubmed:author | pubmed-author:LipceyCC | lld:pubmed |
| pubmed-article:8394695 | pubmed:author | pubmed-author:FrancxM MMM | lld:pubmed |
| pubmed-article:8394695 | pubmed:author | pubmed-author:KlasenSS | lld:pubmed |
| pubmed-article:8394695 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8394695 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8394695 | pubmed:volume | 293 ( Pt 3) | lld:pubmed |
| pubmed-article:8394695 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8394695 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8394695 | pubmed:pagination | 835-42 | lld:pubmed |
| pubmed-article:8394695 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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