| pubmed-article:8385609 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8385609 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:8385609 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8385609 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8385609 | pubmed:dateCreated | 1993-5-13 | lld:pubmed |
| pubmed-article:8385609 | pubmed:abstractText | The lymphocyte-specific protein tyrosine kinase p56lck participates in T cell signaling through functional interactions with components of the T cell antigen receptor complex and the interleukin-2 receptor. Additional insight into the function of p56lck has now been obtained through the generation of transgenic animals expressing high levels of a catalytically inactive form of this kinase (p56lckR273). Mice bearing the lckR273 transgene manifested a severe defect in the production of virtually all T lymphocytes. Those exceptional CD3+ cells that escaped the effects of the lckR273 transgene were confined primarily to the T cell subset that expresses gamma/delta T cell receptors. Remarkably, construction of a dose-response curve for the effects of the lckR273 transgene revealed that developmental arrest of thymocytes occurred at a discrete stage in the normal T cell maturation pathway, corresponding to a point at which thymoblasts ordinarily begin a series of mitotic divisions that result in expansion and maturation. These results suggest that p56lck normally regulates T cell production by metering the replicative potential of immature thymoblasts. | lld:pubmed |
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| pubmed-article:8385609 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8385609 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8385609 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8385609 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8385609 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8385609 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:8385609 | pubmed:author | pubmed-author:PerlmutterR... | lld:pubmed |
| pubmed-article:8385609 | pubmed:author | pubmed-author:AndersonS JSJ | lld:pubmed |
| pubmed-article:8385609 | pubmed:author | pubmed-author:LevinS DSD | lld:pubmed |
| pubmed-article:8385609 | pubmed:author | pubmed-author:ForbushK AKA | lld:pubmed |
| pubmed-article:8385609 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8385609 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:8385609 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8385609 | pubmed:authorsComplete | Y | lld:pubmed |
