pubmed-article:8383297 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8383297 | lifeskim:mentions | umls-concept:C0000768 | lld:lifeskim |
pubmed-article:8383297 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
pubmed-article:8383297 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
pubmed-article:8383297 | lifeskim:mentions | umls-concept:C0205082 | lld:lifeskim |
pubmed-article:8383297 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:8383297 | lifeskim:mentions | umls-concept:C1880287 | lld:lifeskim |
pubmed-article:8383297 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:8383297 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:8383297 | pubmed:issue | 6415 | lld:pubmed |
pubmed-article:8383297 | pubmed:dateCreated | 1993-4-6 | lld:pubmed |
pubmed-article:8383297 | pubmed:abstractText | The Pax genes comprise a family of transcription factors active in specific tissues during embryonic development and are associated with at least three developmental mutations in mouse and man. In the developing kidney, Pax-2 is expressed in the induced mesenchyme, in the ureter epithelium, and in early epithelial structures derived from the mesenchyme. Pax-2 expression is repressed upon terminal differentiation of the renal tubule epithelium, but persists in the undifferentiated epithelium of human Wilms' tumours. We have produced a dominant gain-of-function mutation in transgenic mice by deregulating the expression of the mouse Pax-2 gene. The data obtained with four independently derived transgenic embryos and with one transgenic line demonstrate that deregulated Pax-2 expression results in histologically abnormal and dysfunctional renal epithelium with properties similar to congenital nephrotic syndrome. Thus, repression of Pax-2 is required for normal kidney development and persistent expression of Pax-2 may restrict the differentiation potential of renal epithelial cells. | lld:pubmed |
pubmed-article:8383297 | pubmed:language | eng | lld:pubmed |
pubmed-article:8383297 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8383297 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:8383297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:8383297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8383297 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8383297 | pubmed:month | Mar | lld:pubmed |
pubmed-article:8383297 | pubmed:issn | 0028-0836 | lld:pubmed |
pubmed-article:8383297 | pubmed:author | pubmed-author:PattersonL... | lld:pubmed |
pubmed-article:8383297 | pubmed:author | pubmed-author:WestphalHH | lld:pubmed |
pubmed-article:8383297 | pubmed:author | pubmed-author:WilkinsonJ... | lld:pubmed |
pubmed-article:8383297 | pubmed:author | pubmed-author:DresslerG RGR | lld:pubmed |
pubmed-article:8383297 | pubmed:author | pubmed-author:Williams-Simo... | lld:pubmed |
pubmed-article:8383297 | pubmed:author | pubmed-author:RothenpielerU... | lld:pubmed |
pubmed-article:8383297 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8383297 | pubmed:day | 4 | lld:pubmed |
pubmed-article:8383297 | pubmed:volume | 362 | lld:pubmed |
pubmed-article:8383297 | pubmed:geneSymbol | Pax-2 | lld:pubmed |
pubmed-article:8383297 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8383297 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8383297 | pubmed:pagination | 65-7 | lld:pubmed |
pubmed-article:8383297 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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pubmed-article:8383297 | pubmed:meshHeading | pubmed-meshheading:8383297-... | lld:pubmed |
pubmed-article:8383297 | pubmed:year | 1993 | lld:pubmed |
pubmed-article:8383297 | pubmed:articleTitle | Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities. | lld:pubmed |
pubmed-article:8383297 | pubmed:affiliation | Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892. | lld:pubmed |
pubmed-article:8383297 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8383297 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:8383297 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:18504 | entrezgene:pubmed | pubmed-article:8383297 | lld:entrezgene |
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