Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:8383297rdf:typepubmed:Citationlld:pubmed
pubmed-article:8383297lifeskim:mentionsumls-concept:C0000768lld:lifeskim
pubmed-article:8383297lifeskim:mentionsumls-concept:C0025936lld:lifeskim
pubmed-article:8383297lifeskim:mentionsumls-concept:C0022646lld:lifeskim
pubmed-article:8383297lifeskim:mentionsumls-concept:C0205082lld:lifeskim
pubmed-article:8383297lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:8383297lifeskim:mentionsumls-concept:C1880287lld:lifeskim
pubmed-article:8383297lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:8383297lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:8383297pubmed:issue6415lld:pubmed
pubmed-article:8383297pubmed:dateCreated1993-4-6lld:pubmed
pubmed-article:8383297pubmed:abstractTextThe Pax genes comprise a family of transcription factors active in specific tissues during embryonic development and are associated with at least three developmental mutations in mouse and man. In the developing kidney, Pax-2 is expressed in the induced mesenchyme, in the ureter epithelium, and in early epithelial structures derived from the mesenchyme. Pax-2 expression is repressed upon terminal differentiation of the renal tubule epithelium, but persists in the undifferentiated epithelium of human Wilms' tumours. We have produced a dominant gain-of-function mutation in transgenic mice by deregulating the expression of the mouse Pax-2 gene. The data obtained with four independently derived transgenic embryos and with one transgenic line demonstrate that deregulated Pax-2 expression results in histologically abnormal and dysfunctional renal epithelium with properties similar to congenital nephrotic syndrome. Thus, repression of Pax-2 is required for normal kidney development and persistent expression of Pax-2 may restrict the differentiation potential of renal epithelial cells.lld:pubmed
pubmed-article:8383297pubmed:languageenglld:pubmed
pubmed-article:8383297pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8383297pubmed:citationSubsetIMlld:pubmed
pubmed-article:8383297pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8383297pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8383297pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8383297pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8383297pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8383297pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8383297pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8383297pubmed:statusMEDLINElld:pubmed
pubmed-article:8383297pubmed:monthMarlld:pubmed
pubmed-article:8383297pubmed:issn0028-0836lld:pubmed
pubmed-article:8383297pubmed:authorpubmed-author:PattersonL...lld:pubmed
pubmed-article:8383297pubmed:authorpubmed-author:WestphalHHlld:pubmed
pubmed-article:8383297pubmed:authorpubmed-author:WilkinsonJ...lld:pubmed
pubmed-article:8383297pubmed:authorpubmed-author:DresslerG RGRlld:pubmed
pubmed-article:8383297pubmed:authorpubmed-author:Williams-Simo...lld:pubmed
pubmed-article:8383297pubmed:authorpubmed-author:RothenpielerU...lld:pubmed
pubmed-article:8383297pubmed:issnTypePrintlld:pubmed
pubmed-article:8383297pubmed:day4lld:pubmed
pubmed-article:8383297pubmed:volume362lld:pubmed
pubmed-article:8383297pubmed:geneSymbolPax-2lld:pubmed
pubmed-article:8383297pubmed:ownerNLMlld:pubmed
pubmed-article:8383297pubmed:authorsCompleteYlld:pubmed
pubmed-article:8383297pubmed:pagination65-7lld:pubmed
pubmed-article:8383297pubmed:dateRevised2008-11-21lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:meshHeadingpubmed-meshheading:8383297-...lld:pubmed
pubmed-article:8383297pubmed:year1993lld:pubmed
pubmed-article:8383297pubmed:articleTitleDeregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities.lld:pubmed
pubmed-article:8383297pubmed:affiliationLaboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.lld:pubmed
pubmed-article:8383297pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8383297pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:8383297pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:18504entrezgene:pubmedpubmed-article:8383297lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8383297lld:pubmed