| pubmed-article:8382481 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8382481 | lifeskim:mentions | umls-concept:C0024100 | lld:lifeskim |
| pubmed-article:8382481 | lifeskim:mentions | umls-concept:C0162524 | lld:lifeskim |
| pubmed-article:8382481 | pubmed:dateCreated | 1993-3-23 | lld:pubmed |
| pubmed-article:8382481 | pubmed:abstractText | Vascular endothelial cells, smooth muscle cells, macrophages, neutrophils, Kupffer cells and other diverse cell types generate superoxide (O2.-) and nitric oxide (.NO), which can react to form the potent oxidant peroxynitrite anion (ONOO-). Peroxynitrite reacted with luminol to yield chemiluminescence which was greatly enhanced by bicarbonate. The quantum chemiluminescence yield of the ONOO- reaction with luminol in bicarbonate was approx. 10(-3). Chemiluminescence was superoxide dismutase-inhibitable, indicating that O2.- was a key intermediate for chemiexcitation. O2.- appears to be formed secondarily to the reaction of a bicarbonate-peroxynitrite complex with luminol, yielding luminol radical and O2.-. Luminol radical reacts with O2.- to form the unstable luminol endoperoxide, which follows the light-emitting pathway. Neither .NO nor O2.- alone were capable of directly inducing significant luminol chemiluminescence in our assay systems. These results suggest that ONOO- can be a critical unrecognized mediator of cell-derived luminol chemiluminescence reported in previous studies. In addition, it is shown that bicarbonate can participate in secondary oxidation reactions after reacting with ONOO-. | lld:pubmed |
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| pubmed-article:8382481 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8382481 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8382481 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8382481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8382481 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8382481 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8382481 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:8382481 | pubmed:author | pubmed-author:BeckmanJ SJS | lld:pubmed |
| pubmed-article:8382481 | pubmed:author | pubmed-author:FreemanB ABA | lld:pubmed |
| pubmed-article:8382481 | pubmed:author | pubmed-author:RadiRR | lld:pubmed |
| pubmed-article:8382481 | pubmed:author | pubmed-author:CosgroveT PTP | lld:pubmed |
| pubmed-article:8382481 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8382481 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8382481 | pubmed:volume | 290 ( Pt 1) | lld:pubmed |
| pubmed-article:8382481 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8382481 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8382481 | pubmed:pagination | 51-7 | lld:pubmed |
| pubmed-article:8382481 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:8382481 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8382481 | pubmed:articleTitle | Peroxynitrite-induced luminol chemiluminescence. | lld:pubmed |
| pubmed-article:8382481 | pubmed:affiliation | Department of Anesthesiology, University of Alabama, Birmingham 35233-6810. | lld:pubmed |
| pubmed-article:8382481 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8382481 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8382481 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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