| pubmed-article:8381533 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8381533 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8381533 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:8381533 | lifeskim:mentions | umls-concept:C0026377 | lld:lifeskim |
| pubmed-article:8381533 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:8381533 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8381533 | pubmed:dateCreated | 1993-3-5 | lld:pubmed |
| pubmed-article:8381533 | pubmed:abstractText | For further insight into the role of solvent in protein conformer stabilization, the structural and dynamic properties of protein ions in vacuo have been probed by hydrogen-deuterium exchange in a Fourier-transform mass spectrometer. Multiply charged ions generated by electrospray ionization of five proteins show exchange reactions with 2H2O at 10(-7) torr (1 torr = 133.3 Pa) exhibiting pseudo-first-order kinetics. Gas-phase compactness of the S-S cross-linked RNase A relative to denatured S-derivatized RNase A is indicated by exchange of 35 and 135 hydrogen atoms, respectively. For pure cytochrome c ions, the existence of at least three distinct gaseous conformers is indicated by the substantially different values--52, 113, and 74--of reactive H atoms; the observation of these same values for ions of a number--2, 7, and 5, respectively--of different charge states indicates conformational insensitivity to coulombic forces. For each of these conformers, the compactness in vacuo indicated by these values corresponds directly to that of a known conformer structure in the solution from which the conformer ions are produced by electrospray. S-derivatized RNase A ions also exist as at least two gaseous conformers exchanging 50-140 H atoms. Gaseous conformer ions are isometrically stable for hours; removal of solvent greatly increases conformational rigidity. More specific ion-molecule reactions could provide further details of conformer structures. | lld:pubmed |
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| pubmed-article:8381533 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8381533 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8381533 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8381533 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8381533 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8381533 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8381533 | pubmed:author | pubmed-author:JenK LKL | lld:pubmed |
| pubmed-article:8381533 | pubmed:author | pubmed-author:McLaffertyF... | lld:pubmed |
| pubmed-article:8381533 | pubmed:author | pubmed-author:QuinnJ PJP | lld:pubmed |
| pubmed-article:8381533 | pubmed:author | pubmed-author:ShiYY | lld:pubmed |
| pubmed-article:8381533 | pubmed:author | pubmed-author:SenkoM WMW | lld:pubmed |
| pubmed-article:8381533 | pubmed:author | pubmed-author:SuckauDD | lld:pubmed |
| pubmed-article:8381533 | pubmed:author | pubmed-author:WamplerF... | lld:pubmed |
| pubmed-article:8381533 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8381533 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8381533 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8381533 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8381533 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8381533 | pubmed:pagination | 790-3 | lld:pubmed |
| pubmed-article:8381533 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8381533 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8381533 | pubmed:articleTitle | Coexisting stable conformations of gaseous protein ions. | lld:pubmed |
| pubmed-article:8381533 | pubmed:affiliation | Baker Chemistry Laboratory, Cornell University, Ithaca, NY 14853-1301. | lld:pubmed |
| pubmed-article:8381533 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8381533 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8381533 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8381533 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8381533 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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