Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:8380192rdf:typepubmed:Citationlld:pubmed
pubmed-article:8380192lifeskim:mentionsumls-concept:C0033634lld:lifeskim
pubmed-article:8380192lifeskim:mentionsumls-concept:C0125606lld:lifeskim
pubmed-article:8380192lifeskim:mentionsumls-concept:C0207071lld:lifeskim
pubmed-article:8380192lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:8380192lifeskim:mentionsumls-concept:C1948023lld:lifeskim
pubmed-article:8380192lifeskim:mentionsumls-concept:C0127400lld:lifeskim
pubmed-article:8380192lifeskim:mentionsumls-concept:C0599668lld:lifeskim
pubmed-article:8380192pubmed:issue1lld:pubmed
pubmed-article:8380192pubmed:dateCreated1993-1-25lld:pubmed
pubmed-article:8380192pubmed:abstractTextThe intracellular mechanisms through which two trophic factors, ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF), regulate cholinergic development were examined in sympathetic neuron cultures. Treatment with CNTF or LIF increased levels of choline acetyltransferase (ChAT) activity by 375 and 350%, respectively. However, in neuronal cultures depleted of protein kinase C (PKC) activity by chronic phorbol ester treatment, neither CNTF nor LIF elevated ChAT activity. Further, the stimulation of ChAT due to increased cell density was not observed in PKC-depleted sympathetic neurons. The inhibition of CNTF-stimulated ChAT by phorbol ester occurred in a dose-dependent manner and chronic phorbol ester treatments did not alter the levels of the catecholamine biosynthetic enzyme tyrosine hydroxylase. Moreover, increased levels of diacylglycerol, an endogenous activator of PKC, were observed in sympathetic neurons treated with CNTF. However, neither CNTF nor LIF stimulated the hydrolysis of phosphatidylinositol 4,5-bisphosphate. These observations suggest that a common PKC-dependent pathway, which is independent of phosphatidylinositol 4,5-bisphosphate hydrolysis, mediates the cholinergic stimulating effects of CNTF, LIF, and cell-cell contact in cultured sympathetic neurons.lld:pubmed
pubmed-article:8380192pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:languageenglld:pubmed
pubmed-article:8380192pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:citationSubsetIMlld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8380192pubmed:statusMEDLINElld:pubmed
pubmed-article:8380192pubmed:monthJanlld:pubmed
pubmed-article:8380192pubmed:issn0022-3042lld:pubmed
pubmed-article:8380192pubmed:authorpubmed-author:KesslerJ AJAlld:pubmed
pubmed-article:8380192pubmed:authorpubmed-author:KalbergCClld:pubmed
pubmed-article:8380192pubmed:authorpubmed-author:YungS YSYlld:pubmed
pubmed-article:8380192pubmed:issnTypePrintlld:pubmed
pubmed-article:8380192pubmed:volume60lld:pubmed
pubmed-article:8380192pubmed:ownerNLMlld:pubmed
pubmed-article:8380192pubmed:authorsCompleteYlld:pubmed
pubmed-article:8380192pubmed:pagination145-52lld:pubmed
pubmed-article:8380192pubmed:dateRevised2007-11-15lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:meshHeadingpubmed-meshheading:8380192-...lld:pubmed
pubmed-article:8380192pubmed:year1993lld:pubmed
pubmed-article:8380192pubmed:articleTitleThe cholinergic stimulating effects of ciliary neurotrophic factor and leukemia inhibitory factor are mediated by protein kinase C.lld:pubmed
pubmed-article:8380192pubmed:affiliationDepartment of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461.lld:pubmed
pubmed-article:8380192pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8380192pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:8380192pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8380192lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8380192lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8380192lld:pubmed