| pubmed-article:8377375 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C0023690 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C0041951 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C1522613 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C0205092 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8377375 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8377375 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8377375 | pubmed:dateCreated | 1993-10-20 | lld:pubmed |
| pubmed-article:8377375 | pubmed:abstractText | Renal interstitial fibrosis is a common consequence of chronic ureteral obstruction. While several cytokines may initiate fibrogenesis, TGF-beta is considered to be a major stimulating factor. It has been reported that TGF-beta 1 regulates extracellular matrix (ECM) synthesis, that thromboxane (Tx) stimulates ECM protein synthesis, and that angiotensin II (Ang II) increases expression of TGF-beta 1 mRNA in rat aortic smooth muscle cells. Therefore, we measured TGF-beta 1 mRNA expression by reverse transcription coupled with polymerase chain reaction in renal cortex of rats with unilateral ureteral obstruction (UUO) to determine whether Ang II and/or Tx stimulates increases in TGF-beta 1 mRNA. TGF-beta 1 mRNA levels in contralateral kidneys of rats with UUO did not change significantly during 14 days of obstruction, while in the obstructed kidney TGF-beta 1 mRNA levels were increased significantly after three days as compared to the control (unoperated rats) kidneys. The increase in TGF-beta 1 mRNA expression in the obstructed kidney cortex was found in tubular cells rather than glomeruli. OKY-046, an inhibitor of thromboxane synthase, did not affect the changes in TGF-beta 1 mRNA in the obstructed kidney. Enalapril, an angiotensin I converting enzyme inhibitor, significantly blunted but did not completely abrogate the increase in TGF-beta 1 mRNA. These data suggest that in obstruction TGF-beta 1 is increased at the transcriptional level and thus may play a role in initiating fibrogenesis in obstructive nephropathy. The effect of thromboxane on extracellular matrix synthesis does not appear to be mediated by TGF-beta 1.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:8377375 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8377375 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8377375 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8377375 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8377375 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8377375 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8377375 | pubmed:issn | 0085-2538 | lld:pubmed |
| pubmed-article:8377375 | pubmed:author | pubmed-author:KlahrSS | lld:pubmed |
| pubmed-article:8377375 | pubmed:author | pubmed-author:MorrisseyJJ | lld:pubmed |
| pubmed-article:8377375 | pubmed:author | pubmed-author:KanetoHH | lld:pubmed |
| pubmed-article:8377375 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8377375 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:8377375 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8377375 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8377375 | pubmed:pagination | 313-21 | lld:pubmed |
| pubmed-article:8377375 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8377375 | pubmed:meshHeading | pubmed-meshheading:8377375-... | lld:pubmed |
| pubmed-article:8377375 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8377375 | pubmed:articleTitle | Increased expression of TGF-beta 1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation. | lld:pubmed |
| pubmed-article:8377375 | pubmed:affiliation | Department of Medicine, Jewish Hospital of St. Louis, Washington University Medical Center, Missouri. | lld:pubmed |
| pubmed-article:8377375 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8377375 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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