| pubmed-article:8376802 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8376802 | lifeskim:mentions | umls-concept:C0023281 | lld:lifeskim |
| pubmed-article:8376802 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8376802 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8376802 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:8376802 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:8376802 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:8376802 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:8376802 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:8376802 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:8376802 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:8376802 | pubmed:dateCreated | 1993-10-21 | lld:pubmed |
| pubmed-article:8376802 | pubmed:abstractText | The importance of Ag-specific gamma delta T lymphocytes in human immune responses to pathogenic organisms is unknown. In the present study the expression of gamma delta TCR on T lymphocytes from patients with cutaneous, mucosal, or visceral leishmaniasis was examined. All of these patient groups had elevated levels of gamma delta T cells in peripheral blood. Patients' gamma delta T cells included CD8+ as well as null cells. The percentage of T cells expressing gamma delta TCR was increased significantly by stimulation in vitro with certain parasite Ag. T-cell lines generated by stimulation with promastigote lysates of Leishmania amazonensis or L. braziliensis typically contained 25 to 60% gamma delta T cells. In contrast, two immunodominant surface Ag of L. amazonensis, gp63 and gp42, did not expand gamma delta T cells from infected patients, although both Ag elicited strong alpha beta T-cell responses. gamma delta T cells isolated from a Leishmania-specific T-cell line responded to stimulation with promastigote lysate. Of particular interest, gamma delta T cells from PBMC of a patient with mucosal leishmaniasis responded to stimulation with a recombinant 70 kDa heat shock protein of L. chagasi. This study demonstrated that several clinical forms of leishmaniasis induced elevated numbers of gamma delta T cells that responded specifically to Leishmania Ag in vitro. Therefore, this component of the T-cell response to Leishmania may impact the outcome of clinical disease. | lld:pubmed |
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| pubmed-article:8376802 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8376802 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8376802 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8376802 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8376802 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8376802 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8376802 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8376802 | pubmed:author | pubmed-author:ReedS GSG | lld:pubmed |
| pubmed-article:8376802 | pubmed:author | pubmed-author:GrabsteinK... | lld:pubmed |
| pubmed-article:8376802 | pubmed:author | pubmed-author:RussoD MDM | lld:pubmed |
| pubmed-article:8376802 | pubmed:author | pubmed-author:ArmitageR JRJ | lld:pubmed |
| pubmed-article:8376802 | pubmed:author | pubmed-author:BarralAA | lld:pubmed |
| pubmed-article:8376802 | pubmed:author | pubmed-author:Barral-NettoM... | lld:pubmed |
| pubmed-article:8376802 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8376802 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8376802 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:8376802 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8376802 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8376802 | pubmed:pagination | 3712-8 | lld:pubmed |
| pubmed-article:8376802 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8376802 | pubmed:meshHeading | pubmed-meshheading:8376802-... | lld:pubmed |
| pubmed-article:8376802 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8376802 | pubmed:articleTitle | Antigen-reactive gamma delta T cells in human leishmaniasis. | lld:pubmed |
| pubmed-article:8376802 | pubmed:affiliation | Seattle Biomedical Research Institute, Washington 98109. | lld:pubmed |
| pubmed-article:8376802 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8376802 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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