| pubmed-article:8376767 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8376767 | lifeskim:mentions | umls-concept:C0524984 | lld:lifeskim |
| pubmed-article:8376767 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8376767 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:8376767 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:8376767 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:8376767 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:8376767 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:8376767 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:8376767 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:8376767 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:8376767 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8376767 | pubmed:dateCreated | 1993-10-20 | lld:pubmed |
| pubmed-article:8376767 | pubmed:abstractText | The development of TCR-gamma delta cells during thymic ontogeny has been studied using fetal thymic organ cultures of normal and transgenic (Tg) mice. The expression of the cell-surface markers--heat stable Ag (HSA), MEL-14, CD5, CD25 (IL-2R), and CD44 (Pgp-1)--correlated with TCR-gamma delta maturation. As the fetal thymus developed, there was an increase in HSA-, CD5dull, and CD44+ cells for each TCR-gamma delta cell subset. Moreover, the expression of recombination activating genes-1 and -2 (RAG-1 and RAG-2) also correlated with TCR-gamma delta maturation as only HSA+ TCR-gamma delta cells transcribed these genes. Cyclosporin A inhibited the development of the TCR-gamma delta thymocytes if it was introduced early during thymic ontogeny by arresting the differentiation of TCR-gamma delta thymocytes at the HSA+ stage. Immature HSA+ TCR-gamma delta thymocytes isolated from both TCR-gamma delta Tg and normal mice did not respond to nominal Ag or anti-TCR mAb unless exogenous IL-2 was added to the cultures. In contrast, HSA- TCR-gamma delta cells from Tg and normal mice responded to TCR/ligand interactions in the absence of additional IL-2. Finally, the development of functionally mature TCR-gamma delta cells could be induced in vitro. Interaction of the HSA+ Tg+ TCR-gamma delta cells with anti-TCR-gamma delta mAb or Ag-bearing thymic stromal cells resulted in RAG-1 and RAG-2 down-regulation. These data strongly suggest that TCR-gamma delta HSA+, RAG+ thymocytes differentiate into a more mature stage under the pressure of positive selection and that TCR-gamma delta cell development is regulated in a manner similar to TCR-alpha beta cells. In addition, the ability of Cyclosporin A to inhibit TCR-gamma delta cell development combined with the findings that Ag-bearing stromal cells can induce Tg TCR-gamma delta cell development suggests that maturation and selection of TCR-gamma delta cells depends on receptor-mediated physiologic stimuli delivered during thymic development. | lld:pubmed |
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| pubmed-article:8376767 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8376767 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8376767 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8376767 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8376767 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8376767 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8376767 | pubmed:author | pubmed-author:BluestoneJ... | lld:pubmed |
| pubmed-article:8376767 | pubmed:author | pubmed-author:TatsumiYY | lld:pubmed |
| pubmed-article:8376767 | pubmed:author | pubmed-author:DelucaDD | lld:pubmed |
| pubmed-article:8376767 | pubmed:author | pubmed-author:MatisLL | lld:pubmed |
| pubmed-article:8376767 | pubmed:author | pubmed-author:PenaJ CJC | lld:pubmed |
| pubmed-article:8376767 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8376767 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8376767 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:8376767 | pubmed:geneSymbol | RAG-1 | lld:pubmed |
| pubmed-article:8376767 | pubmed:geneSymbol | RAG-2 | lld:pubmed |
| pubmed-article:8376767 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8376767 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8376767 | pubmed:pagination | 3030-41 | lld:pubmed |
| pubmed-article:8376767 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8376767 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8376767 | pubmed:articleTitle | Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation. | lld:pubmed |
| pubmed-article:8376767 | pubmed:affiliation | Ben May Institute, Department of Pathology, University of Chicago, IL 60637. | lld:pubmed |
| pubmed-article:8376767 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8376767 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8376767 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8376767 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8376767 | lld:pubmed |
