| pubmed-article:8372044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8372044 | lifeskim:mentions | umls-concept:C0040822 | lld:lifeskim |
| pubmed-article:8372044 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8372044 | lifeskim:mentions | umls-concept:C0036104 | lld:lifeskim |
| pubmed-article:8372044 | lifeskim:mentions | umls-concept:C0020672 | lld:lifeskim |
| pubmed-article:8372044 | lifeskim:mentions | umls-concept:C0242947 | lld:lifeskim |
| pubmed-article:8372044 | lifeskim:mentions | umls-concept:C0680727 | lld:lifeskim |
| pubmed-article:8372044 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:8372044 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8372044 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:8372044 | pubmed:issue | 4-5 | lld:pubmed |
| pubmed-article:8372044 | pubmed:dateCreated | 1993-10-12 | lld:pubmed |
| pubmed-article:8372044 | pubmed:abstractText | Hypothermia, tremor and salivation induced by muscarinic cholinergic agonists were studied in mice. Oxotremorine-M (quarternary agonist) shows high potency after intracerebroventricular administration, but the potency is low after subcutaneous administration. Oxotremorine potency (non-quarternary agonist) is higher after intracerebroventricular administration than after subcutaneous administration. Scopolamine and atropine (non-quarternary antagonists) antagonize oxotremorine-induced effects more potently after intracerebroventricular than subcutaneous administration. The quarternary antagonists N-methylscopolamine (NMS) and N-methylatropine (NMA) potently antagonize oxotremorine-induced salivation after both subcutaneous and intracerebroventricular administration. Hypothermia is antagonized partially (20-40%) over a large dose range after subcutaneous administration. In ex vivo receptor-binding studies of rat brain tissue, oxotremorine, scopolamine and atropine administered subcutaneously dose-dependently displace 3H-oxotremorine-M. Oxotremorine-M and NMS displace 3H-oxotremorine-M by 21% and 35%, respectively; NMA is ineffective. In conclusion: Muscarinic cholinergic-mediated tremor is centrally regulated; hypothermia involves both a central and a peripheral component, the peripheral regulation being relatively less important than the central; central and peripheral regulation of salivation are equally important. Penetration of the blood brain barrier by oxotremorine-M and NMS is shown in the ex vivo binding studies. | lld:pubmed |
| pubmed-article:8372044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8372044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8372044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8372044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8372044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8372044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8372044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8372044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8372044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8372044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8372044 | pubmed:issn | 0901-9928 | lld:pubmed |
| pubmed-article:8372044 | pubmed:author | pubmed-author:MeierEE | lld:pubmed |
| pubmed-article:8372044 | pubmed:author | pubmed-author:SánchezCC | lld:pubmed |
| pubmed-article:8372044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8372044 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:8372044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8372044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8372044 | pubmed:pagination | 262-7 | lld:pubmed |
| pubmed-article:8372044 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8372044 | pubmed:meshHeading | pubmed-meshheading:8372044-... | lld:pubmed |
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| pubmed-article:8372044 | pubmed:meshHeading | pubmed-meshheading:8372044-... | lld:pubmed |
| pubmed-article:8372044 | pubmed:meshHeading | pubmed-meshheading:8372044-... | lld:pubmed |
| pubmed-article:8372044 | pubmed:meshHeading | pubmed-meshheading:8372044-... | lld:pubmed |
| pubmed-article:8372044 | pubmed:meshHeading | pubmed-meshheading:8372044-... | lld:pubmed |
| pubmed-article:8372044 | pubmed:meshHeading | pubmed-meshheading:8372044-... | lld:pubmed |
| pubmed-article:8372044 | pubmed:meshHeading | pubmed-meshheading:8372044-... | lld:pubmed |
| pubmed-article:8372044 | pubmed:articleTitle | Central and peripheral mediation of hypothermia, tremor and salivation induced by muscarinic agonists in mice. | lld:pubmed |
| pubmed-article:8372044 | pubmed:affiliation | Pharmacological Research, H. Lundbeck A/S, Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:8372044 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8372044 | pubmed:publicationType | Comparative Study | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8372044 | lld:pubmed |
